Ventilator-associated events in children: A multicentre prospective cohort study

Autor: Yolanda Peña-López, Magda Campins-Martí, Maria Slöcker-Barrio, Amaya Bustinza, Carme Alejandre, Iolanda Jordán-García, Ana Ortiz-Álvarez, Jose Domingo López-Castilla, Elena Pérez, Cristina Schüffelmann, María García-Besteiro, Silvia Sánchez-Pérez, David Arjona, Ana Coca-Pérez, Juan Carlos De Carlos, Jose Carlos Flores-González, Mikel Mendizabal, Jose Manuel Sánchez-Granados, María Carmen Martínez-Padilla, Rosalía Pérez, Ana Abril-Molina, Sofia Tejada, David Roca, Marta Serrano-Megías, Jordi Rello
Rok vydání: 2022
Předmět:
Zdroj: ANAESTHESIA CRITICAL CARE & PAIN MEDICINE
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname
ISSN: 2352-5568
Popis: Background: The Centres for Disease Control and Prevention (CDC) broadened the focus of surveillance from ventilator-associated pneumonia to ventilator-associated event (VAE) for quality purposes. No paediatric definition of VAE (PaedVAE) has been accurately validated. We aimed to analyse the incidence and impact on patient outcomes resulting from the application of the adult and two paediatric VAE (PaedVAE) criteria. Secondary objective: to evaluate VAE/PaedVAE as factors associated with increased duration of mechanical ventilation (MV) and Paediatric Intensive Care Unit (PICU) stay. Methods: Multicentre observational prospective cohort study in 15 PICUs in Spain. VAEs were assessed using the 2013/2015 CDC classification. PaedVAE were assessed using the CDC definition based on mean airway pressure (MAP-PaedVAE) versus a paediatric definition based on positive end-expiratory pressure (PEEP-PaedVAE). Children who underwent MV > 48 h were included. Results: A total of 3626 ventilator-days in 391 patients were analysed. The incidence of VAE, MAP-PaedVAE and PEEP-PaedVAE was 8.55, 5.24 and 20.96 per 1000 ventilator-days, respectively. The median time [IQR] for VAE, MAP-PaedVAE and PEEP-PaedVAE development from the MV onset was 4 [3-12.5], 4 [3-14], and 5 [3-7.75] days, respectively. Among survivors, all three were associated with increased MV duration (> 7 days) and PICU stay (> 10 days) at univariate analysis. Multivariate analysis showed that PEEP-PaedVAE was the only definition independently associated with MV above 7 days [OR = 4.86, 95% CI (2.41-10.11)] and PICU stay [OR = 3.49, 95% CI (1.68-7.80)] above ten days, respectively. Conclusions: A VAE definition based on slight PEEP increases should be preferred for VAE surveillance in children.(C) 2022 Societefranc , aise d'anesthesie et de reanimation (Sfar). Published by Elsevier Masson SAS. All rights reserved.
Databáze: OpenAIRE
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