Preclinical evaluations of acellular biological conduits for peripheral nerve regeneration
| Autor: | Paarun Patel, Cunqi Cui, Hui Xu, Shijie Qi, Wendell Q. Sun, Hua Wan, I-Chien Liao |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Pathology
medicine.medical_specialty Biomedical Engineering Nerve guidance conduit regenerative medicine Medicine (miscellaneous) Peripheral nerve regeneration Regenerative medicine Article lcsh:Biochemistry Biomaterials Dermis medicine lcsh:QD415-436 Clinical significance Axon mesenchymal stem cells business.industry Mesenchymal stem cell Muscle atrophy Surgery medicine.anatomical_structure nerve guide decellularized tissue medicine.symptom business Artery |
| Zdroj: | Journal of Tissue Engineering, Vol 4 (2013) Journal of Tissue Engineering |
| ISSN: | 2041-7314 |
| DOI: | 10.1177/2041731413481036 |
| Popis: | Various types of natural biological conduits have been investigated as alternatives to the current surgical standard approach for peripheral nerve injuries. Autologous nerve graft, the current gold standard for peripheral nerve damage, is limited by clinical challenges such as donor-site morbidity and limited availability. The purpose of this study was to evaluate the efficacy of using acellular xenographic conduits (nerve, artery, and dermis) for the repair of a 1.2 cm critical size defect of peripheral nerve in a rodent model. Four months post surgery, the animal group receiving acellular artery as a nerve conduit showed excellent physiological outcome in terms of the prevention of muscle atrophy and foot ulcer. Histological assessment of the bridged site revealed excellent axon regeneration, as opposed to the nonrepaired control group or the group receiving dermal conduit. Finally, the study evaluated the potential improvement via the addition of undifferentiated mesenchymal stem cells into the artery conduit during the bridging procedure. The mesenchymal stem cell–dosed artery conduit group resulted in significantly higher concentration of regenerated axons over artery conduit alone, and exhibited accelerated muscle atrophy rescue. Our results demonstrated that xenographic artery conduits promoted excellent axonal regeneration with highly promising clinical relevance. |
| Databáze: | OpenAIRE |
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