Estrogenic Effect of the Extract of QingYan Formula on Reproductive Tissues in Immature Mice
| Autor: | Na Lin, Hong-Xia Zheng, Yuan Zhao, Ying Xu |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Article Subject medicine.drug_class Uterus Estrogen receptor Biology 03 medical and health sciences 0302 clinical medicine Downregulation and upregulation Internal medicine medicine 030304 developmental biology Estrous cycle 0303 health sciences lcsh:Other systems of medicine lcsh:RZ201-999 medicine.anatomical_structure Endocrinology Complementary and alternative medicine Estrogen 030220 oncology & carcinogenesis Vagina Luteinizing hormone hormones hormone substitutes and hormone antagonists Research Article Hormone |
| Zdroj: | Evidence-Based Complementary and Alternative Medicine, Vol 2019 (2019) Evidence-based Complementary and Alternative Medicine : eCAM |
| ISSN: | 1741-4288 1741-427X |
| DOI: | 10.1155/2019/5493714 |
| Popis: | A Chinese herbal preparation, QingYan formula (QYF), has been used clinically for kidney-invigorating. However, no evidence base links QYF to estrogen replacement therapy. In this study, the estrogenic effects of QingYan formula 70% ethanol extract (QYFE) were investigated in immature mice. Immature mice were treated with QYFE at doses of 1, 2, and 4g/kg for 7 days. QYFE treatments promoted vaginal cornification and prolonged the estrus status of the immature mice, promoted the growth and development of uterus and vagina, upregulated ERα and ERβ expression at protein level in uterus and vagina, increased the level of estradiol (E2), and decreased concentration of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in serum. This study demonstrated that QYFE exerts estrogenic effects by stimulating biosynthesis of estrogen and increasing estrogen receptors (ERs) in target tissues and provided an evidence base for QYFE treatment instead of estrogen replacement therapy. |
| Databáze: | OpenAIRE |
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