The Spectrum of Glomerulopathies in Kashmir: A Tertiary Care Experience
| Autor: | Ibrahim Masoodi, Irshad A Sirwal |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Nephrotic Syndrome Adolescent Biopsy Kidney Glomerulus 030232 urology & nephrology Lupus nephritis India Adenocarcinoma 030204 cardiovascular system & hematology Kidney Glomerulonephritis Membranous Gastroenterology Diabetic nephropathy Young Adult 03 medical and health sciences Glomerulonephritis 0302 clinical medicine Stomach Neoplasms Internal medicine medicine Humans Minimal change disease Renal Insufficiency Aged Retrospective Studies Aged 80 and over Glomerulosclerosis Focal Segmental Tertiary Healthcare business.industry Nephrosis Lipoid Renal vein thrombosis Middle Aged medicine.disease Lupus Nephritis Venous thrombosis Hypertension Female Kidney Diseases Histopathology business Nephrotic syndrome |
| Zdroj: | Nephron. 139:237-242 |
| ISSN: | 2235-3186 1660-8151 |
| Popis: | Background: There is a paucity of data on the spectrum of renal diseases prevalent in the Jammu and Kashmir region. Objectives: To determine the spectrum of glomerulopathies in adult patients attending a tertiary care centre. Methods: Two hundred and twenty-one adequate biopsies from native kidneys of adult patients who presented with features suggestive of glomerular diseases at Sheri Kashmir Institute of medical sciences Srinagar Kashmir for the last 8 years were studied in a retrospective manner. Light and immunofluorescence (IF) microscopy were performed to evaluate these biopsies after obtaining well-informed consent from each patient. Results: Of the 221 biopsies carried out, 150 were performed on males and 71 on females with the mean age of 29 ± 13.5 years. The main presentation was the nephrotic syndrome in 177 (80%), hypertension in 60 (27%), renal insufficiency in 48 (21.7%), and abnormal urinary sediment in 42 (20.3%) of patients. The histopathology revealed minimal change disease (MCD) in 69 (31.2%), membranous glomerulonephritis (MGN) in 48 (21.7%), focal segmental glomerulsclerosis (FSG) in 49 (18%), and mesangioproliferative glomerulonephritis in 16 (7.2%). Patients with atypical presentation of diabetes mellitus showed diabetic nephropathy in 12 (5.4%) patients. Lupus nephritis was in 5 (2.2%) patients. Majority of the patients with MPGN had Immunoglobulin A deposits on IF. While evaluating the underlying cause of MGN, only 1 patient, a 62-year-old male, proved to have adenocarcinoma of the stomach. In the remaining patients, no secondary cause could be found. Thrombotic complications seen in our study were deep venous thrombosis, renal vein thrombosis and middle cerebral artery thrombosis. Conclusion: MCD and MGN were the most common primary glomerular diseases observed in our centre. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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