| Autor: |
Shanhui Li, Yonglin Zhu, Fangang Fu, Guofeng Zhang, Bai-Sui Zhou, Shanrun Zhao, Chengzhen Jin, Chuanbo Li |
| Rok vydání: |
2020 |
| Předmět: |
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| DOI: |
10.21203/rs.3.rs-18944/v1 |
| Popis: |
Introduction: Osteosarcoma (OS) patients with complete surgical resection still relapse with poor prognosis. Part of this is due to the inability to accurately detect distant metastasis. Thus it’s enssential to identify metastasis-related biomarkers for OS.Methods: In present study, a computational pipeline based on relative expression orderings (REOs) using gene expression proles was constructed in metastases and non-metastases OS patients. Results: 138 metastasis-associated gene pair signature (MGPS) were identified follow two independent datasets. In order to further extract metastasis-associated biomarker for clinical application, a metastases-specific co-expressed MGPS network was constructed and analyzed. MGPS such as MYL5 and RPL27A showed strong positive correlation (Cor =0.75, P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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