Highly Retina-Permeating and Long-Acting Resveratrol/Metformin Nanotherapeutics for Enhanced Treatment of Macular Degeneration

Autor:	Duc Dung Nguyen, Li-Jyuan Luo, Chia-Jung Yang, Jui-Yang Lai
Rok vydání:	2022
Předmět:	General Engineering General Physics and Astronomy General Materials Science
Zdroj:	ACS Nano. 17:168-183
ISSN:	1936-086X 1936-0851
DOI:	10.1021/acsnano.2c05824
Popis:	The development of therapeutics for effective treatments of retinal diseases is significantly constrained by various biological barriers. We herein report a nanomedicine strategy to develop nanotherapeutics featured with not only high retinal permeability but also sustained bioactive delivery. Specifically, the nanotherapeutics are rationally designed via aminolysis of resveratrol-encapsulated polycaprolactone nanoparticles (R@PCL NPs), followed by the formation of amide linkages with carboxyl-terminated transacting activator of transcription cell penetrating peptide (T) and metformin (M). The R@PCL-T/M NP nanotherapeutics are demonstrated
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a76a8e9509dd8b234dc77b0d079d43d https://doi.org/10.1021/acsnano.2c05824 Zobrazit plný text záznamu