Breast-conserving surgery in breast cancer and intraoperative radiotherapy. Can we predict the fibrosis?
| Autor: | Juan Pelegrín Sánchez Marín, María Carmen Casamayor Franco, Jesús Víctor Pérez-Tierra Ruiz, Yaiza Martínez Lahoz, Cristina Vallejo Bernad, María Victoria Barra Pardos, Aurora Carrasquer Puyal, José Luis Pallarés Segura |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Radiobiology medicine.medical_treatment Breast Neoplasms 030230 surgery Abnormalities Radiation-Induced Mastectomy Segmental 03 medical and health sciences 0302 clinical medicine Breast cancer Transforming Growth Factor beta Fibrosis medicine Breast-conserving surgery Humans Breast Prospective Studies Aged Intraoperative Care Radiotherapy business.industry General Engineering Surgical wound Middle Aged medicine.disease Radiation therapy Biomarker (medicine) Female Radiology business Intraoperative radiotherapy |
| Zdroj: | Cirugía Española (English Edition). 97:517-522 |
| ISSN: | 2173-5077 |
| DOI: | 10.1016/j.cireng.2019.10.008 |
| Popis: | Radiotherapy techniques associated with breast-conserving surgery have evolved in early breast cancer thanks to a better knowledge of tumor radiobiology, highlighting intraoperative radiotherapy (IORT). However, complications have been documented with this procedure, mainly fibrosis. Transforming growth factor beta (TGF-β) is a cytokine with an active role in radiation-induced fibrosis, which could be used as an early biomarker for the development of fibrosis.Multicentric prospective analysis of 60 patients with breast cancer who underwent breast-conserving surgery, 30 of whom had received additional IORT. TGF-β values were evaluated in serum pre-surgery and in serum collected 24h after surgery. In addition, we evaluated surgical wound fluids collected 6h and 24h following surgery.Serum and surgical wound fluids TGF-β values collected over 24h following surgery were significantly higher in patients who received additional IORT (P.0001). Notably, 8 of these patients showed values above 1,000pg/ml. There were no differences between the samples (serum or surgical wound fluids) (P=.5881).Although further investigation is needed, higher TGF-β values in IORT during breast-conserving surgery can be used as an early biomarker for the development of fibrosis. |
| Databáze: | OpenAIRE |
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