Lack of clinical and physiological relationship between gastrin and calcitonin in man
| Autor: | Daubresse Jc, Brassine A, Paul Franchimont, G. Heynen, J. A. Kanis, S. Gaspar, G Ligny |
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| Rok vydání: | 1981 |
| Předmět: |
Adult
Calcitonin Male medicine.medical_specialty Clinical Biochemistry chemistry.chemical_element Stimulation Calcium digestive system Biochemistry Basal (phylogenetics) Calcium Chloride Internal medicine Anemia Pernicious Gastrins Medicine Humans Gastrin business.industry digestive oral and skin physiology General Medicine Calcitonin secretion Pentagastrin Endocrinology chemistry Duodenal Ulcer Gastritis Injections Intravenous Dietary Proteins medicine.symptom business hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | European journal of clinical investigation. 11(4) |
| ISSN: | 0014-2972 |
| Popis: | The clinical and physiological relevance of the relationship between gastrin and calcitonin has been investigated in normal subjects and in patients suffering from gastritis or duodenal ulcer. Basal plasma levels of calcitonin are increased in these patients but there is no significant relationship between calcitonin and gastrin levels. Acute pentagastrin injection in normal male subjects increased significantly (P less than 0.05) plasma calcitonin levels whereas lower doses of pentagastrin which are known to stimulate gastric secretion are without effect on calcitonin levels. Moreover, stimulation of gastrin secretion by a protein test meal and by intragastric administration of a calcium chloride solution is not followed by any significant increase of plasma calcitonin levels. These results suggest that the stimulation of calcitonin secretion by gastrin and its synthetic analogue pentagastrin is a pharmacological rather than a physiological phenomenon. |
| Databáze: | OpenAIRE |
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