Re-appraising the potential of naringin for natural, novel orthopedic biotherapies
| Autor: | Inkyu Lee, Kristin E. Yu, Alana M. Munger, Francis Y. Lee, Montana T Morris, Hyuk-Kwon Kwon, Jung Ho Back, Sean V. Cahill, Kareme D Alder |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Osteolysis Bone disease Cellular differentiation Osteoporosis Review Diseases of the musculoskeletal system Bone morphogenetic protein 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Rheumatology medicine Orthopedics and Sports Medicine Naringin osteoclastogenesis biology naringin business.industry Wnt signaling pathway osteomyelitis medicine.disease osteoporosis osteoarthritis 030104 developmental biology chemistry RC925-935 RANKL 030220 oncology & carcinogenesis diabetes mellitus biology.protein Cancer research business |
| Zdroj: | Therapeutic Advances in Musculoskeletal Disease, Vol 12 (2020) Therapeutic Advances in Musculoskeletal Disease |
| ISSN: | 1759-7218 |
| Popis: | Naringin is a naturally occurring flavonoid found in plants of the Citrus genus that has historically been used in traditional Chinese medical regimens for the treatment of osteoporosis. Naringin modulates signaling through numerous molecular pathways critical to musculoskeletal development, cellular differentiation, and inflammation. Administration of naringin increases in vitro expression of bone morphogenetic proteins (BMPs) and activation of the Wnt/β-catenin and extracellular signal-related kinase (Erk) pathways, thereby promoting osteoblastic proliferation and differentiation from stem cell precursors for bone formation. Naringin also inhibits osteoclastogenesis by both modifying RANK/RANKL interactions and inducing apoptosis in osteoclasts in vitro. In addition, naringin acts on the estrogen receptor in bone to mimic the native bone-preserving effects of estrogen, with few systemic side effects on other estrogen-sensitive tissues. The efficacy of naringin therapy in reducing the osteolysis characteristic of common musculoskeletal pathologies such as osteoporosis, degenerative joint disease, and osteomyelitis, as well as inflammatory conditions affecting bone such as diabetes mellitus, has been extensively demonstrated in vitro and in animal models. Naringin thus represents a naturally abundant, cost-efficient agent whose potential for use in novel musculoskeletal biotherapies warrants re-visiting and further exploration through human studies. Here, we review the cellular mechanisms of action that have been elucidated regarding the action of naringin on bone resident cells and the bone microenvironment, in vivo evidence of naringin’s osteostimulative and chondroprotective properties in the setting of osteolytic bone disease, and current limitations in the development of naringin-containing translational therapies for common musculoskeletal conditions. |
| Databáze: | OpenAIRE |
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