Two-year performance of a Nestorone®-releasing contraceptive implant: a three-center study of 300 women
| Autor: | Rebeca Massai, Horacio B. Croxatto, Ana Sofia Tejeda, Alfred J. Moo-Young, Verónica Reyes, Luis Bahamondes, Irving Sivin, Janet Schechter, Elaine Travers, Esther Wu, Vivian Brache, Arthur Allen, Sirpa Ranta, Narender Kumar, Francisco J. Alvarez |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
medicine.medical_specialty Patient Dropouts Adolescent Population 03 medical and health sciences 0302 clinical medicine Pregnancy Contraceptive Agents Female medicine Humans 030212 general & internal medicine education Menstruation Disturbances Drug Implants Analysis of Variance education.field_of_study Chi-Square Distribution 030219 obstetrics & reproductive medicine Obstetrics business.industry Obstetrics and Gynecology Pregnancy Unwanted 3. Good health Surgery Discontinuation Clinical trial Pregnancy rate Treatment Outcome Reproductive Medicine Family planning Female Implant Contraceptive implant business Pearl Index Brazil Norprogesterones Follow-Up Studies |
| Zdroj: | Contraception. 69:137-144 |
| ISSN: | 0010-7824 |
| DOI: | 10.1016/j.contraception.2003.10.003 |
| Popis: | A 2-year trial of a single Nestorone® (NES) rod implant was conducted at three Latin American centers, each enrolling 100 women. We studied the safety, effectiveness and acceptability of this progestin-releasing contraceptive implant. Three pregnancies occurred, the last at 18 months of use. Because no pregnancies were expected in the first 18 months, the trial was halted. At that time, 224 women had completed at least 18 months of use, and 99 women had used the implant for more than 24 months. Few participants used adjunctive contraception between the time the study was halted and the time they had their implant removed. No additional pregnancies occurred before the removal of the last implant. The 2-year cumulative pregnancy rate was 1.7 per 100 with a Pearl index of 0.6 per 100 for the 2-year period. The 1-year and 2-year continuation rates were 80.5 and 66.7 per 100, respectively. Menstrual and medical disturbances were the principal reasons for discontinuation, followed by planned pregnancy. Headache and weight gain frequently led to discontinuation. The NES implant had little important effect on most clinical chemistry and lipid parameters. Over the study course, the mean change in hemoglobin was |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect