Childhood-Onset Essential Hypertension and the Family Structure
| Autor: | S. Shahrukh Hashmi, Dianna M. Milewicz, Sanjay Shete, Michelle S. Barratt, Monesha Gupta-Malhotra |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Proband medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism Mothers 030204 cardiovascular system & hematology Essential hypertension Article 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Internal Medicine Humans Medicine Prospective Studies 030212 general & internal medicine Age of Onset Child business.industry Family structure Infant Odds ratio Single mothers medicine.disease Single Parent Confidence interval Pedigree Case-Control Studies Child Preschool Hypertension Female Essential Hypertension Cardiology and Cardiovascular Medicine business |
| Zdroj: | The Journal of Clinical Hypertension. 18:431-438 |
| ISSN: | 1524-6175 |
| DOI: | 10.1111/jch.12701 |
| Popis: | The prevalence and effect of single-parent families in childhood-onset essential hypertension (EH) is unknown. Children with EH and age-, sex-, and ethnicity-matched controls were enrolled. Family structure data were obtained by in-person interview. A total of 148 families (76 hypertension probands, 72 control probands; median 14 years) were prospective-ly enrolled in the study. Single-parent status was seen in 42% of the families--with and without EH (38% vs 46%, P=.41; odds ratio, 0.7; 95% confidence interval, 0.4-1.4). After multivariable analysis, a statistically significant sociofamilial contributor to the development of childhood-onset EH was not identified. A significant number of single-parent families (42%), the majority with single mothers, were found in our pedigree study. Sociofamilial factors are known to contribute to the expression of adult-onset EH, but findings in our study suggest that they appear to contribute less in the expression of childhood-onset EH. |
| Databáze: | OpenAIRE |
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