Phase 2 trial of daily, oral epigallocatechin gallate in patients with light-chain amyloidosis
| Autor: | Yuko M. Sagesaka, Yuuichi Ukawa, Sohsuke Meshitsuka, Masanori Nojima, Miku Goto, Kenshi Suzuki, Makoto Kobayashi, Yasuyo Wada, Masatoshi Hotta, Sumito Shingaki |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Antioxidant medicine.medical_treatment 030204 cardiovascular system & hematology Epigallocatechin gallate Pharmacology medicine.disease_cause complex mixtures Antioxidants Catechin 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine AL amyloidosis Humans heterocyclic compounds Immunoglobulin Light-chain Amyloidosis Adverse effect Aged Aged 80 and over Tea business.industry Amyloidosis food and beverages Hematology Middle Aged medicine.disease Oxidative Stress Treatment Outcome chemistry 030220 oncology & carcinogenesis Toxicity Albuminuria Female sense organs medicine.symptom business Reactive Oxygen Species Oxidative stress |
| Zdroj: | International journal of hematology. 105(3) |
| ISSN: | 1865-3774 |
| Popis: | Previous studies have suggested that an increase in mitochondrial reactive oxygen species may cause organ damage in patients with light-chain (AL) amyloidosis; however, this damage can be decreased by antioxidant-agent treatment. Epigallocatechin gallate (EGCG), the major natural catechin in green tea, has potent antioxidant activity. Because EGCG has recently been reported to have a favorable toxicity profile for treating amyloidosis, we sought to examine the clinical efficacy and toxicity of EGCG in patients with AL amyloidosis. Fifty-seven patients were randomly assigned to the EGCG and observation groups and observed for six months. There were no increases in grade 3–5 adverse events and EGCG therapy was well tolerated. Although a decrease in the urinary albumin level was found in the EGCG group in patients with obvious albuminuria after treatment initiation, its antioxidant activity may not be sufficient to clarify the potential effect of EGCG in patients with AL amyloidosis. Because some of the biological markers responsible for organ damage were well correlated to the level of antioxidant potential in patients’ plasma, the status of oxidative stress in the blood may indicate the extent of organ damage in clinical situations. |
| Databáze: | OpenAIRE |
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