Staphylococcus aureus in a neonatal care center: methicillin-susceptible strains should be a main concern

Autor: Thiolat, A., Biton, J., Decker, P., Semerano, L., Boissier, C., Pers, Y., Jorgensen, C., Plence, P. Louis, Bessis, N., Romano-Bertrand, Sara, Filleron, Anne, Mesnage, Renaud, Lotthé, Anne, Didelot, Marie, Burgel, Lydie, Bilak, Estelle, Cambonie, Gilles, Parer, Sylvie
Přispěvatelé: Institut de biologie moléculaire et cellulaire (IBMC), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), UPRES EA-3408, UFR SMBH. Service de Rhumatologie, Hôpital Avicenne AP-HP, Université Paris 13 (UP13), MARine Biodiversity Exploitation and Conservation (UMR MARBEC), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Institut de Recherche pour le Développement (IRD), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Ecologie des systèmes marins côtiers (Ecosym), Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Hôpital Arnaud de Villeneuve [CHRU Montpellier], Hôpital de la Colombière
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Microbiology (medical)
Pediatrics
medicine.medical_specialty
Staphylococcus aureus
[SDV]Life Sciences [q-bio]
Context (language use)
Drug resistance
Antibiotic resistance
Medical microbiology
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
medicine
Prevalence
Infection control
Pharmacology (medical)
ComputingMilieux_MISCELLANEOUS
[SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics
Catheter-related infections
business.industry
Incidence (epidemiology)
Research
Public Health
Environmental and Occupational Health
Outbreak
White coat contamination
3. Good health
Infectious Diseases
Methicillin-susceptible Staphylococcus aureus
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Methicillin Susceptible Staphylococcus Aureus
business
Zdroj: Antimicrobial Resistance and Infection Control
Antimicrobial Resistance and Infection Control, BioMed Central, 2014, 3 (1), pp.2640-2641. ⟨10.1186/2047-2994-3-21⟩
Antimicrobial Resistance and Infection Control, BioMed Central, 2014, 3, pp.21. ⟨10.1186/2047-2994-3-21⟩
ISSN: 2047-2994
DOI: 10.1186/2047-2994-3-21⟩
Popis: International audience; Background: In the context of a methicillin-susceptible Staphylococcus aureus (MSSA) outbreak, we aimed to improve our knowledge of S. aureus (SA) epidemiology in the neonatal care center (NCC) of a tertiary care teaching hospital.Methods: We performed a complete one-year review of SA carrier, colonized or infected patients. Monthly prevalence and incidence of SA intestinal carriage, colonization and infection were calculated and the types of infection analysed. During the MSSA outbreak, strains were studied for antimicrobial resistance, content of virulence genes and comparative fingerprint in Pulsed-Field Gel Electrophoresis. Hand hygiene and catheter-related practices were assessed by direct observational audits. Environmental investigation was performed in search of a SA reservoir.Results: Epidemiological analyses showed 2 or 3 prevalence peaks on a background of SA endemicity. In the NCC, during 2009, overall MSSA prevalence did not decrease below 5.5%, while mean MRSA prevalence was about 1.53%. Analysis of infection cases revealed that the outbreak corresponded to the emergence of catheter-related infections and was probably related to the relaxation in infection control practices in a context of high colonization pressure. Health care workers’ white coats appeared as a potential environmental reservoir that could perpetuate SA circulation in the ward.Conclusion: This report emphasizes the importance of integrating MSSA along with methicillin-resistant SA in a program of epidemiological surveillance in the NCC.
Databáze: OpenAIRE
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