Hemoglobin: Structure, Function and Allostery
| Autor: | Martin K. Safo, Mostafa H. Ahmed, Mohini S. Ghatge |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Physiological function 030102 biochemistry & molecular biology Chemistry Allosteric regulation Structure function Hemoglobin variants Ligands Hematologic Diseases Article Oxygen Hemoglobins 03 medical and health sciences 030104 developmental biology Allosteric Regulation Biophysics Humans Hemoglobin Oxygen binding Function (biology) Synthetic ligands |
| Zdroj: | Subcellular Biochemistry ISBN: 9783030417680 Subcell Biochem |
| DOI: | 10.1007/978-3-030-41769-7_14 |
| Popis: | This chapter reviews how allosteric (heterotrophic) effectors and natural mutations impact hemoglobin (Hb) primary physiological function of oxygen binding and transport. First, an introduction about the structure of Hb is provided, including the ensemble of tense and relaxed Hb states and the dynamic equilibrium of Hb multistate. This is followed by a brief review of Hb variants with altered Hb structure and oxygen binding properties. Finally, a review of different endogenous and exogenous allosteric effectors of Hb is presented with particular emphasis on the atomic interactions of synthetic ligands with altered allosteric function of Hb that could potentially be harnessed for the treatment of diseases. |
| Databáze: | OpenAIRE |
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