Does tumor extent on needle prostatic biopsies influence the value of perineural invasion to predict pathologic stage > T2 in radical prostatectomies?
| Autor: | Luis Alberto Magna, Ubirajara Ferreira, Luciana Rodrigues de Meirelles, Athanase Billis, Leandro Freitas, Maisa M. Quintal |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Multivariate analysis Urology medicine.medical_treatment Perineural invasion lcsh:RC870-923 prostatic neoplasms needle Biopsy medicine Carcinoma Humans Neoplasm Invasiveness biopsy Stage (cooking) Aged Neoplasm Staging Retrospective Studies Univariate analysis Analysis of Variance prostate medicine.diagnostic_test prostatectomy business.industry Prostatectomy Biopsy Needle Middle Aged medicine.disease lcsh:Diseases of the genitourinary system. Urology prognosis business Radical retropubic prostatectomy |
| Zdroj: | International Brazilian Journal of Urology, Vol 36, Iss 4, Pp 439-449 (2010) International braz j urol, Volume: 36, Issue: 4, Pages: 439-449, Published: AUG 2010 International braz j urol v.36 n.4 2010 International Braz J Urol Sociedade Brasileira de Urologia (SBU) instacron:SBU |
| ISSN: | 1677-6119 1677-5538 |
| Popis: | PURPOSE: Perineural invasion (PNI) on needle prostatic biopsies (NPB) has been controversial as a marker of extraprostatic extension and consequently for planning of nerve-sparing radical prostatectomy (RP). The aim of this study was to find whether tumor extent on NPB influences the value of PNI to predict stage > pT2 on RP. MATERIALS AND METHODS: This retrospective study was based on 264 consecutive patients submitted to radical retropubic prostatectomy. Their NPB were matched with whole-mount processed and totally embedded surgical specimens. Tumor extent on NPB was evaluated as the percentage of linear tissue in mm containing carcinoma in all cores. Considering the median value, patients were stratified into 2 groups: harboring less or more extensive tumors on NPB. Univariate and multivariate logistic regression analyses were used to relate stage > pT2 to PNI and other clinical and pathological variables. RESULTS: In patients with more extensive tumors, PNI was predictive of stage > pT2 in univariate analysis but not in multivariate analysis. In less extensive tumors, PNI showed no association between any clinical or pathological variables studied; no difference in the time to biochemical progression-free status compared to patients without PNI; and, no predictive value for pathological stage > pT2 on both univariate and multivariate analyses. CONCLUSION: Tumor extent on NPB influences the predictive value of PNI for pathologic stage > pT2 on RP. With a higher number of small tumors currently detected, there is no evidence that perineural invasion should influence the decision on preservation of the nerve during radical prostatectomy. |
| Databáze: | OpenAIRE |
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