Therapeutic Potential of Endothelial Progenitor Cells in the Field of Orthopaedics
| Autor: | Yohei Kawakami, Ryosuke Kuroda, Tomoyuki Matsumoto, Tomoaki Fukui, Kunj G. Patel, Garth N. Walker, Masahiro Kurosaka, Yutaka Mifune |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Bone Regeneration Angiogenesis CD34 Medicine (miscellaneous) 03 medical and health sciences 0302 clinical medicine Vasculogenesis Animals Humans Medicine Progenitor cell Bone regeneration Endothelial Progenitor Cells Clinical Trials as Topic business.industry Chemotaxis General Medicine Surgery Endothelial stem cell Orthopedics 030104 developmental biology 030220 oncology & carcinogenesis embryonic structures cardiovascular system Cancer research Musculoskeletal regeneration Stem cell business Stem Cell Transplantation circulatory and respiratory physiology |
| Zdroj: | Current Stem Cell Research & Therapy. 12:3-13 |
| ISSN: | 1574-888X |
| DOI: | 10.2174/1574888x11666160810102945 |
| Popis: | Inadequate blood supply frequently impedes the viability of tissue-engineered constructs in the initial phase after implantation, and can lead to improper cell integration or cell death. Vascularization using stem cells has continued to evolve as a potential solution to this problem. In this review, we summarize studies that utilize endothelial progenitor cells (EPCs) for musculoskeletal regeneration. This review will also highlight recent concepts for EPC identification in conjunction with the development of EPC biology research. EPCs promote bone regeneration in animal models through a variety of mechanisms. By differentiating toward endothelial cell lineages and osteoblasts, EPCs stimulate vasculogenesis, angiogenesis and osteogenesis. Moreover, EPCs influence supporting cells through the secretion of growth factors and cytokines. Phase I/II clinical trials have applied circulating CD34+ cells/EPCs to nonunion bone fractures and have exhibited promising results including accelerated bone healing. Similar mechanisms of angiogenesis and osteogenesis are proposed for anterior cruciate ligament (ACL) ruptured tissue derived CD34+ cells, and thus EPCs have implied a critical role at the site of tendon-bone integration. EPCs are an emerging strategy among other cell-based therapies in the field of orthopaedics for the promotion of musculoskeletal regeneration. |
| Databáze: | OpenAIRE |
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