Role of non-invasive markers in prediction of esophageal varices and variceal bleeding in patients of alcoholic liver cirrhosis from central India
| Autor: | Amol R Samarth, Sudhir Jagdishoprasad Gupta, Nitin R Gaikwad, Harit G. Kothari, Tushar H. Sankalecha |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Alcoholic liver disease medicine.medical_specialty Cirrhosis India Esophageal and Gastric Varices Gastroenterology Esophageal varices Liver Cirrhosis Alcoholic Predictive Value of Tests Internal medicine medicine Humans Endoscopy Digestive System Univariate analysis medicine.diagnostic_test Esophagogastroduodenoscopy business.industry AST/ALT ratio Middle Aged medicine.disease Cross-Sectional Studies Portal hypertension Original Article business Varices Gastrointestinal Hemorrhage |
| Zdroj: | The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology. 30(12) |
| ISSN: | 2148-5607 |
| Popis: | BACKGROUND/AIMS: Alcohol is the leading cause of liver cirrhosis, which results in portal hypertension and subsequently, culminates into esophageal varices and esophgeal variceal bleeding. Esophagogastroduodenoscopy is gold standard for diagnosis of varices. Non-invasive markers based on clinical, laboratory & ultrasonographic parameters can be utilised for prediction of risk of esophageal varices & variceal bleed in alcoholic cirrhosis from central India. MATERIALS AND METHODS: This was a cross sectional observational study. Child Turcot Pugh scores, MELD, AST ALT Ratio(AAR), AST Platelet Ratio Index(APRI), FIB-4 index and Platelet count-Spleen diameter(PC/SD) ratio were calculated for all patients and correlated with esophagogastroduodenoscopy findings. Short term follow up was done for variceal bleeding. RESULTS: Total 202 male patients were included with mean age of 43.77±9.95 years. 188(93%) patients had esophageal varices. 61(30.19%) patients had variceal bleeding. On univariate analysis platelet count, APRI, spleen bipolar diameter, and PC/SD ratio were significantly associated with varices. For prediction of esophageal varices, only PC/SD ratio was significant and showed area under the curve of 65.6% at cut-off of |
| Databáze: | OpenAIRE |
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