Neuroprotective effect of α-mangostin on mitochondrial dysfunction and α-synuclein aggregation in rotenone-induced model of Parkinson's disease in differentiated SH-SY5Y cells

Autor:	Xin-Mei Hao, Chang-Ling Duan, Lian-Da Li, Yu-Juan Li
Rok vydání:	2017
Předmět:	0301 basic medicine SH-SY5Y Parkinson's disease Cell Survival Xanthones Pharmaceutical Science Apoptosis Pharmacology Neuroprotection Analytical Chemistry 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Rotenone Drug Discovery medicine Autophagy Humans Cytotoxicity Caspase Membrane potential chemistry.chemical_classification Membrane Potential Mitochondrial Reactive oxygen species biology Dose-Response Relationship Drug Molecular Structure Organic Chemistry Parkinson Disease General Medicine medicine.disease 030104 developmental biology Neuroprotective Agents Complementary and alternative medicine chemistry Biochemistry biology.protein alpha-Synuclein Molecular Medicine Reactive Oxygen Species 030217 neurology & neurosurgery
Zdroj:	Journal of Asian natural products research. 19(8)
ISSN:	1477-2213
Popis:	The study was designed to evaluate the protective effect of α-mangostin and explore its mechanism in an in vitro model of Parkinson’s disease (PD) induced by rotenone. SH-SY5Y cells were treated with rotenone and α-mangostin for 24 h. α-Mangostin significantly and concentration-dependently inhibited rotenone-induced cytotoxicity. The rotenone-induced aggregation of α-synuclein and loss of TH were alleviated by α-mangostin. α-Mangostin treatment also reversed the rotenone-induced overproduction of reactive oxygen species, activation of caspases (−8 and −3) and mitochondrial dysfunction, reflected by decrease in mitochondrial membrane potential and cellular ATP levels. These findings suggest that α-mangostin has neuroprotective effects against PD-related neuronal injury.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a12b12344b53343b0bdaa020c2c855b https://pubmed.ncbi.nlm.nih.gov/28696167 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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