Analytical Differences in Intraoperative Parathyroid Hormone Assays
| Autor: | Peter Angelos, Edwin L. Kaplan, David A. Sarracino, Raymon H. Grogan, Bryan Krastins, Edward Ki Yun Leung, Christine C. Lee, Kiang-Teck J. Yeo, Mary F. Lopez, Theodore Karrison |
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| Rok vydání: | 2018 |
| Předmět: |
Parathyroidectomy
Immunoassay Male medicine.medical_specialty business.industry medicine.medical_treatment Significant difference Urology Parathyroid hormone Clinical Chemistry Tests General Medicine 030204 cardiovascular system & hematology Middle Aged Hyperparathyroidism Primary 03 medical and health sciences Intraoperative Period 0302 clinical medicine Parathyroid Hormone Medicine Humans Female 030212 general & internal medicine business Surgical patients |
| Zdroj: | The journal of applied laboratory medicine. 3(5) |
| ISSN: | 2576-9456 |
| Popis: | Background We compared the rates of intraoperative parathyroid hormone (PTH) decline using the Siemens Immulite® Turbo PTH and Roche Elecsys® short turnaround time PTH assays in 95 consecutive surgical patients to investigate analytical and turnaround time (TAT) differences between the tests performed in the operating room (OR) vs the central clinical chemistry laboratory (CCL). Methods Serial blood samples from 95 patients undergoing parathyroidectomy were collected and measured using the 2 immunoassays. Specimens from the first 15 patients were measured simultaneously in the OR and CCL and used for the TAT study. In addition to 2 baseline samples, specimens were collected at 5, 10, and 15 min (for some patients, >15 min) after parathyroidectomy. Results In the TAT study, a significant difference was observed (OR median 20 min vs CCL median 27 min; P < 0.05). Of the 95 patient series, slower rates of parathyroid hormone decrease were observed in approximately 20% of the patients when comparing the Roche with the Immulite immunoassay. Conclusions There was a slightly longer TAT in the CCL compared with running the assay directly within the OR (median difference of approximately 7 min). For a majority of the patients, both methods showed equivalent rates of PTH decline; however, for approximately 20% of the patients, there was a slower rate of PTH decline using the Roche assay. |
| Databáze: | OpenAIRE |
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