Cytotoxic Effects of Betel Quid and Areca Nut Aqueous Extracts on Mouse Fibroblast, Human Mouth-Ordinary-Epithelium 1 and Human Oral Squamous Cell Carcinoma Cell Lines
| Autor: | Norifumi Nakamura, Masitah Hayati Harun, Toshiro Kibe, Badr Abdullah Al-Tayar, Michiko Kishida, Shosei Kishida, Noor Khairiena Mohamad, Azlina Ahmad, Siti Nurnasihah Md Hashim, Mohamad Ezany Yusoff, Siti Fadilah Abdullah |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Nut Cell Survival betel quid Apoptosis cell lines Biology Mice 03 medical and health sciences 0302 clinical medicine Areca nut medicine Animals Humans Nuts Cytotoxic T cell MTT assay Neoplasms Glandular and Epithelial Viability assay Cytotoxicity Fibroblast Areca Cells Cultured Traditional medicine Plant Extracts digestive oral and skin physiology General Medicine oral cancer Fibroblasts biology.organism_classification stomatognathic diseases 030104 developmental biology medicine.anatomical_structure Cell culture 030220 oncology & carcinogenesis Carcinoma Squamous Cell cytotoxicity Mouth Neoplasms Research Article |
| Zdroj: | Asian Pacific Journal of Cancer Prevention : APJCP |
| ISSN: | 2476-762X |
| Popis: | Background: Betel quid chewing is more common among the older generation in rural areas of Malaysia. Oral cancer in Asia has been associated with the habit of chewing betel quid and areca nut. Objective: This study aims to investigate the cytotoxic effects of betel quid and areca nut extracts on the fibroblast (L929), mouth-ordinary-epithelium 1 (MOE1) and oral squamous cell carcinoma (HSC-2) cell lines. Methods: L929, MOE1 and HSC-2 cells were treated with 0.1, 0.2 and 0.4 g/ml of betel quid and areca nut extracts for 24, 48 and 72 h. MTT assay was performed to assess the cell viability. Results: Both extracts, regardless of concentration, significantly reduced the cell viability of L929 compared with the control (P |
| Databáze: | OpenAIRE |
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