Quantitative alterations of CD8+ T cells in juvenile idiopathic arthritis patients in remission
| Autor: | Lothar Bernd Zimmerhackl, Michaela Sailer-Höck, Hannelore Kern, Nora Schwarzenbrunner, Martina Prelog, Juergen Brunner, Elisabeth Tengg |
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| Rok vydání: | 2008 |
| Předmět: |
Male
musculoskeletal diseases medicine.medical_specialty Adolescent T cell CD3 Arthritis chemical and pharmacologic phenomena CD8-Positive T-Lymphocytes Flow cytometry CD28 Antigens Rheumatology immune system diseases Internal medicine medicine Humans Cytotoxic T cell L-Selectin Child biology medicine.diagnostic_test business.industry Remission Induction Age Factors CD28 hemic and immune systems General Medicine medicine.disease Arthritis Juvenile Lymphocyte Subsets Treatment Outcome medicine.anatomical_structure Endocrinology Child Preschool Immunology biology.protein Leukocyte Common Antigens Female business CD8 |
| Zdroj: | Clinical Rheumatology. 28:385-389 |
| ISSN: | 1434-9949 0770-3198 |
| DOI: | 10.1007/s10067-008-1057-z |
| Popis: | The study was aimed to investigate whether quantities of CD8(+) T cell subsets are normal in juvenile idiopathic arthritis (JIA) patients with disease remission compared to age-matched healthy donors (HD) and whether chronological age may have an impact on proportions of naive CD8(+) T cells. CD8(+) T cell subsets were analyzed in 17 JIA patients and 32 age-matched HD by flow cytometry. JIA patients showed lower CD3(+)CD8(+) T cells compared to HD. Total counts of CD8(+)CD28(+) and CD8(+)CD28(+)CD45RA(+) T cells were inversely correlated to chronological age in JIA patients and HD. In JIA patients, percentages of CD8(+)CD28(+)CD45RA(+) T cells and of CD62L-expressing CD8(+)CD28(+)CD45RA(+) T cells showed a negative correlation with age. The trend to lower CD28(+)CD45RA(+) T cell proportions in aged JIA patients in remission may reflect a disturbed T cell homeostasis independently of disease activity and may be due to an intrinsic effect in reconstitution of the peripheral T cells. |
| Databáze: | OpenAIRE |
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