Increased micronucleus frequencies in reticulocytes of children exposed to industrial pollution: oxidative stress and the OGG1 S326C polymorphism

Autor:	Francisco Mercado-Calderón, Rosa Beltrán-Portugal, Luis Serrano-García, Luis Fernando Oropeza-Hernández, Selene Herrera-Morales, Regina Montero-Montoya, Leticia Hernández-Cadena, Isaías Galicia-Alonso, Esmeralda Alvarado-Toledo, Alejandra Méndez-Serrano, Arnulfo Albores-Medina, Omar Arellano-Aguilar, Guadalupe García-Vargas, Samuel Rosado-Zaidi, Rocío López-Vargas
Rok vydání:	2019
Předmět:	0301 basic medicine Male medicine.medical_specialty Reticulocytes Adolescent Genotype Health Toxicology and Mutagenesis Transferrin receptor 010501 environmental sciences Biology Industrial pollution medicine.disease_cause 01 natural sciences DNA Glycosylases 03 medical and health sciences Internal medicine Genetics medicine Humans Child 0105 earth and related environmental sciences Micronucleus Tests Polymorphism Genetic Oxidative Stress 030104 developmental biology Endocrinology Female Micronucleus Environmental Pollution Oxidative stress Biomarkers
Zdroj:	Mutation research. Genetic toxicology and environmental mutagenesis. 853
ISSN:	1879-3592
Popis:	We examined possible early-effect biomarkers and polymorphisms of susceptibility in primary school children living near the Atoyac River in central Mexico, which receives waste from multiple industries. We observed a significant increase in micronucleated reticulocytes associated with the oxidative stress index (OSI) and the OGG1 GG (S326C) genotype, and a significant decrease of reticulocytes carrying the transferrin receptor, inversely correlated with OSI.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19f33b89b14e828bb8cb211cc72a1c76 https://pubmed.ncbi.nlm.nih.gov/32522350 Zobrazit plný text záznamu Full Text from ScienceDirect