Vasoactive intestinal peptide and substance P-like immunoreactivities in the enteric nervous system of the pig correlate with the severity of pathological changes induced by Schistosoma japonicum
| Autor: | M.V Johansen, Onesmo B. Balemba, Anders Hay-Schmidt, W. D. Semuguruka, Vibeke Dantzer |
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| Rok vydání: | 2001 |
| Předmět: |
medicine.medical_specialty
Colon Swine Vasoactive intestinal peptide Substance P Inflammation Biology Enteric Nervous System Schistosoma japonicum chemistry.chemical_compound Immune system Internal medicine medicine Animals Intestinal Mucosa Cecum Swine Diseases Nervous tissue biology.organism_classification Immunohistochemistry Infectious Diseases Endocrinology medicine.anatomical_structure chemistry Schistosomiasis japonica Enterochromaffin cell Parasitology Enteric nervous system medicine.symptom Vasoactive Intestinal Peptide |
| Zdroj: | International journal for parasitology. 31(13) |
| ISSN: | 0020-7519 |
| Popis: | Limited studies have shown that in intestinal schistosomosis, the enteric nervous tissue becomes inflamed, disrupted and destroyed by granulomas and peptides, amines and neurofilaments contents are altered. Therefore, immunoreactivities of vasoactive intestinal peptide and substance P were correlated to pathological lesions in the large intestine from pigs infected with Schistosoma japonicum. Ganglia situated within or near granulomas showed ganglionitis, and necrosis of neurons as well as infiltration by eosinophils, mast cells, lymphocytes, plasma cells, neutrophils and macrophages. The inner submucous and mucous plexuses were the most damaged. In all categories of inflamed areas, the vasoactive intestinal peptide-like immunoreactive was reduced in all plexuses whereas, that of substance P was increased both in the enteric nerve plexuses and enterochromaffin cells in lightly, moderately and severely inflamed tissues. However, both peptides were highly diminished or absent in very severe lesions and areas surrounding schistosome eggs and mature worms laying eggs in the submucosal veins. The alterations of the levels of vasoactive intestinal peptide and substance P were correlated with severity of inflammation. Our observations show alterations of vasoactive intestinal peptide and substance P contents in the local microenvironment in the vasoactive intestinal peptide- and substance P-mediated reflex pathways which regulate intestinal motility, epithelial transport and modulate immunity. These changes could cause alterations in bowel motility, electrolyte and fluid secretion, vascular and immune functions during S. japonicum infections in the pig. This may, therefore, partly play a role in the pathobiology of migration and egress of schistosome eggs as well as influence trapping of eggs in granulomas, and account for diarrhoea, loss of body weight and failure to thrive, which are recorded in schistosomosis. |
| Databáze: | OpenAIRE |
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