Effects of Acute Hypoglycemia on Working Memory and Language Processing in Adults With and Without Type 1 Diabetes
| Autor: | Kate V. Allen, Robert J. Hartsuiker, Brian M. Frier, Martin J. Pickering, Ian J. Deary, Matthew J. Traxler, Nicola N. Zammitt |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Research design
Adult Blood Glucose Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Hypoglycemia Audiology Medical and Health Sciences Endocrinology & Metabolism Young Adult Memory Clinical Research Diabetes mellitus Behavioral and Social Science Diabetes Mellitus Internal Medicine medicine Humans Psychological testing Young adult Pathophysiology/Complications Metabolic and endocrine Pediatric Advanced and Specialized Nursing Type 1 diabetes Language Disorders Memory Disorders Psychological Tests Working memory business.industry Diabetes Cognition medicine.disease Diabetes Mellitus Type 1 Memory Short-Term Short-Term Case-Control Studies Acute Disease Female business Type 1 |
| Zdroj: | Diabetes Care Diabetes care, vol 38, iss 6 Allen, K V, Pickering, M J, Zammitt, N N, Hartsuiker, R J, Traxler, M J, Frier, B M & Deary, I J 2015, ' Effects of acute hypoglycemia on working memory and language processing in adults with and without type 1 diabetes ', Diabetes Care . https://doi.org/10.2337/dc14-1657 |
| ISSN: | 1935-5548 0149-5992 |
| DOI: | 10.2337/dc14-1657 |
| Popis: | OBJECTIVE To examine the effects of hypoglycemia on language processing in adults with and without type 1 diabetes. RESEARCH DESIGN AND METHODS Forty adults were studied (20 with type 1 diabetes and 20 healthy volunteers) using a hyperinsulinemic glucose clamp to lower blood glucose to 2.5 mmol/L (45 mg/dL) (hypoglycemia) for 60 min, or to maintain blood glucose at 4.5 mmol/L (81 mg/dL) (euglycemia), on separate occasions. Language tests were applied to assess the effects of hypoglycemia on the relationship between working memory and language (reading span), grammatical decoding (self-paced reading), and grammatical encoding (subject-verb agreement). RESULTS Hypoglycemia caused a significant deterioration in reading span (P < 0.001; η2 = 0.37; Cohen d = 0.65) and a fall in correct responses (P = 0.005; η2 = 0.19; Cohen d = 0.41). On the self-paced reading test, the reading time for the first sentence fragment increased during hypoglycemia (P = 0.039; η2 = 0.11; Cohen d = 0.25). For the reading of the next fragment, hypoglycemia affected the healthy volunteer group more than the adults with type 1 diabetes (P = 0.03; η2 = 0.12; Cohen d = 0.25). However, hypoglycemia did not significantly affect the number of errors in sentence comprehension or the time taken to answer questions. Hypoglycemia caused a deterioration of subject-verb agreement (correct responses: P = 0.011; η2 = 0.159; Cohen d = 0.31). CONCLUSIONS Hypoglycemia caused a significant deterioration in reading span and in the accuracy of subject-verb agreement, both of which are practical aspects of language involved in its everyday use. Language processing is therefore impaired during moderate hypoglycemia. |
| Databáze: | OpenAIRE |
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