Gastric electrical stimulation is associated with improvement in pancreatic exocrine function in humans
| Autor: | Warren Starkebaum, Hani Rashed, Benoit Marchal, Thomas O'Dorisio, Jean Luo, Thomas L. Abell, Amar Al-Juburi |
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| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_specialty Gastroparesis Endocrinology Diabetes and Metabolism Drug Resistance Electric Stimulation Therapy Pancreatic Polypeptide Gastroenterology Feces Endocrinology Heart Rate Internal medicine Heart rate Internal Medicine Medicine Pancreatic polypeptide Heart rate variability Humans Hepatology Pancreatic Elastase business.industry Elastase Fasting medicine.disease Postprandial Period Pancreas Exocrine Electrodes Implanted Postprandial medicine.anatomical_structure Exocrine Pancreatic Insufficiency Female Analysis of variance business Pancreas |
| Zdroj: | Pancreas. 29(2) |
| ISSN: | 1536-4828 |
| Popis: | OBJECTIVE To define the possible effects of gastric electrical stimulation (GES) for gastroparesis on pancreatic function, we performed 2 related human studies. METHODS Fecal elastase values were compared in 2 patient groups: (1) GES devices ON and (2) GES devices OFF and (2) in 3 control groups: (1) no response (NR) to prokinetic medications, (2) positive response (RES) to medications, and (3) normal controls. Polypeptide levels in 7 of 9 GES patients with device ON and OFF, elastase results, GI symptoms (TSS), and heart rate variability (HRV) were compared by paired t tests and/or ANOVA and reported as mean +/- SE. RESULTS Elastase was different for GES-ON and OFF (508.0 +/- 92.2 vs. GES-OFF 378.6 +/- 87.4, P < 0.05). Elastase was lower in medication NR and RES than in normal controls. Postprandial pancreatic polypeptide was greater with GES ON than OFF (P = 0.07). HRV revealed a lower percentage of change with device ON versus OFF (44.2 +/- 5.5 vs. 48.5 +/- 5.2, P = 0.08) and lower TSS with ON versus OFF (15.9 +/- 4.5 vs. 25.7 +/- 5.3, P < 0.05). CONCLUSIONS GES improves exocrine pancreatic release, effects autonomic control, and improves GI symptoms, suggesting a possible role for GES in the treatment of pancreatic insufficiency associated with gastroparesis. |
| Databáze: | OpenAIRE |
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