Clonidine and phenylephrine injected into the lateral hypothalamus inhibits water intake in rats
| Autor: | José Vanderlei Menani, Wilson Abrão Saad, Antonio Renzi, Laurival Antonio De Luca Junior, Luiz Antonio de Arruda Camargo, Antonio Carlos Ferrari |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
medicine.medical_specialty Lateral hypothalamus Drinking In Vitro Techniques Clonidine Injections Thirst Eating Phenylephrine Internal medicine medicine Prazosin Animals Molecular Biology Injections Intraventricular Dehydration Chemistry Angiotensin II General Neuroscience Yohimbine Rats Endocrinology Hypothalamus Hypothalamic Area Lateral Neurology (clinical) medicine.symptom Developmental Biology medicine.drug |
| Zdroj: | Brain Research. 522:125-130 |
| ISSN: | 0006-8993 |
| Popis: | It has been demonstrated that peripheral or intracerebroventricular (i.c.v.) administration of the alpha 2-adrenoceptor agonist, clonidine, blocks the water intake induced by several dipsogenic stimuli in rats. In the present investigation we studied the effect of the injection of clonidine, phenylephrine, prazosin or yohimbine into the lateral hypothalamic area (LHA) on the water intake induced by water deprivation or central angiotensin II (AII) in rats. Rats with chronic cannulas implanted into the lateral ventricle and LHA were used. Injection of clonidine or phenylephrine into the LHA reduced the water intake produced by both water deprivation and i.c.v. injection of AII. Previous injection of the alpha 1- or alpha 2-adrenoceptor antagonists, prazosin or yohimbine, into the LHA reduced the antidipsogenic effect of clonidine or phenylephrine injected into the same area. These results suggest that the alpha 1- and alpha 2-adrenergic receptors of the hypothalamus are part of the central inhibitory system for the thirst produced by dehydration or central AII. |
| Databáze: | OpenAIRE |
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