Association of basal metabolic rate and fuel oxidation in basal conditions and during exercise, with plasma S-klotho: the FIT-AGEING study
| Autor: | Jonatan R. Ruiz, Francisco J. Amaro-Gahete, Manuel J. Castillo, Alejandro De-la-O, Lucas Jurado-Fasoli |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Chronological ageing
Male medicine.medical_specialty Aging Energy metabolism MFO basal fat oxidation urologic and male genital diseases Basal (phylogenetics) Oxygen Consumption Fat oxidation Internal medicine medicine Humans Graded exercise test Klotho Exercise Klotho Proteins Glucuronidase Chemistry Calorimetry Indirect Cell Biology Fat max Middle Aged Endocrinology Adipose Tissue Ageing Basal metabolic rate basal metabolic rate Female Basal Metabolism Oxidation-Reduction Research Paper |
| Zdroj: | Aging (Albany NY) |
| ISSN: | 1945-4589 |
| Popis: | S-klotho, the shed form of α-klotho, is thought to be an ageing suppressor with functions related to the physiology of energy metabolism. However, it remains unknown whether ageing biomarkers such as S-klotho and/or chronological ageing are associated in any way with basal metabolic rate (BMR) and fuel oxidation in basal conditions and during exercise. The present work investigates the association of BMR and fuel oxidation in basal conditions and during exercise, with plasma S-klotho in middle-aged, sedentary adults. BMR was measured by indirect calorimetry in 74 such subjects (53% women; age 53.7±5.1 years) following standard procedures, and their fuel oxidation estimated via stoichiometric equations. The maximal fat oxidation during exercise (MFO) and the intensity of exercise that elicits MFO (Fatmax) were determined using a walking graded exercise test. No relationship was seen between BMR and plasma S-klotho (P>0.1), although both basal fat oxidation and MFO showed positive associations with this protein (both P0.1). The present findings suggest that basal fat oxidation and MFO are strongly associated with plasma S-klotho in middle-aged sedentary adults. These results support the idea that metabolic flexibility is a powerful predictor of biological ageing. |
| Databáze: | OpenAIRE |
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