Anti-arthritic effects demonstrated by an interleukin-2 receptor-targeted cytotoxin (DAB486IL-2) in rat adjuvant arthritis
| Autor: | Patricia Bacha, Jean C. Nichols, David E. Trentham, Stuart J. Perper, Serene E. Forte |
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| Rok vydání: | 1992 |
| Předmět: |
Interleukin 2
Time Factors Recombinant Fusion Proteins medicine.medical_treatment Immunology Arthritis Inflammation Lymphocyte Activation medicine Animals Immunology and Allergy Diphtheria Toxin Receptor biology business.industry Receptors Interleukin-2 Immunotherapy medicine.disease Arthritis Experimental Rats Radiography Cytokine Rats Inbred Lew Rheumatoid arthritis biology.protein Interleukin-2 Female Antibody medicine.symptom business medicine.drug |
| Zdroj: | European Journal of Immunology. 22:1673-1679 |
| ISSN: | 1521-4141 0014-2980 |
| DOI: | 10.1002/eji.1830220702 |
| Popis: | DAB486IL-2 is an interleukin-2 receptor-specific cytotoxin which selectively targets and kills cells which bear the high-affinity form of the IL-2 receptor. Since elimination of activated T lymphocytes may be useful in the treatment of rheumatoid arthritis, the effect of DAB486IL-2 treatment in an animal model of arthritis was investigated. We demonstrated that rats treated with DAB486IL-2 during the induction phase of disease have delayed onset of symptoms and significantly reduced severity of inflammation as well as a depressed proliferative response to mycobacterial stimulation in vitro. In addition, the presence of preexisting antibodies to the molecule had no impact on the anti-arthritic effects observed in this model. These data suggest that DAB486IL-2 may have therapeutic potential in the treatment of rheumatoid arthritis. |
| Databáze: | OpenAIRE |
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