Sulfated polysaccharide-based scaffolds for orthopaedic tissue engineering
| Autor: | Jeremy Dinoro, Megan S. Lord, Mahboubeh Jafarkhani, Javad Foroughi, Gorka Orive, Mehdi Mehrali, Sepehr Talebian, Malachy Maher, Alireza Dolatshahi-Pirouz |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Engineering
Biophysics Bioengineering Retention capacity Nanotechnology Biocompatible Materials 02 engineering and technology Biomaterials 03 medical and health sciences Tissue engineering Polysaccharides Biological property Animals Humans Bone 030304 developmental biology Sulfated polysaccharides 0303 health sciences Tissue Engineering Tissue Scaffolds business.industry Hydrogels 021001 nanoscience & nanotechnology Chondrogenesis Reconstructive and regenerative medicine Radboud Institute for Molecular Life Sciences [Radboudumc 10] Cartilage Mechanics of Materials Self-healing hydrogels Ceramics and Composites 0210 nano-technology business Growth factors |
| Zdroj: | Dinoro, J, Maher, M, Talebian, S, Jarfarkhani, M, Mehrali, M, Orive, G, Foroughi, J, Lord, M S & Dolatshahi-Pirouz, A 2019, ' Sulfated polysaccharide-based scaffolds for orthopaedic tissue engineering ', Biomaterials, vol. 214, 119214 . https://doi.org/10.1016/j.biomaterials.2019.05.025 Biomaterials, 214, pp. 119214 Biomaterials, 214, 119214 |
| ISSN: | 0142-9612 |
| DOI: | 10.1016/j.biomaterials.2019.05.025 |
| Popis: | Item does not contain fulltext Given their native-like biological properties, high growth factor retention capacity and porous nature, sulfated-polysaccharide-based scaffolds hold great promise for a number of tissue engineering applications. Specifically, as they mimic important properties of tissues such as bone and cartilage they are ideal for orthopaedic tissue engineering. Their biomimicry properties encompass important cell-binding motifs, native-like mechanical properties, designated sites for bone mineralisation and strong growth factor binding and signaling capacity. Even so, scientists in the field have just recently begun to utilise them as building blocks for tissue engineering scaffolds. Most of these efforts have so far been directed towards in vitro studies, and for these reasons the clinical gap is still substantial. With this review paper, we have tried to highlight some of the important chemical, physical and biological features of sulfated-polysaccharides in relation to their chondrogenic and osteogenic inducing capacity. Additionally, their usage in various in vivo model systems is discussed. The clinical studies reviewed herein paint a promising picture heralding a brave new world for orthopaedic tissue engineering. 01 september 2019 |
| Databáze: | OpenAIRE |
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