Prognostic Significance of Lymphatic, Venous and Perineural Invasion After Neoadjuvant Chemotherapy in Patients with Gastric Adenocarcinoma
| Autor: | Anantha Madhavan, Claire L. Donohoe, Alexander W. Phillips, Benjamin L. Woodham, Jakub Chmelo |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Perineural invasion Adenocarcinoma Gastroenterology Young Adult 03 medical and health sciences 0302 clinical medicine Gastrectomy Stomach Neoplasms Surgical oncology Internal medicine medicine Humans Neoplasm Invasiveness Peripheral Nerves Stage (cooking) Lymph node Survival rate Neoadjuvant therapy Aged Neoplasm Staging Retrospective Studies Aged 80 and over Gastrointestinal Oncology business.industry Cancer Middle Aged Prognosis medicine.disease Neoadjuvant Therapy Survival Rate medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Lymph Node Excision Female 030211 gastroenterology & hepatology Surgery business |
| Zdroj: | Annals of Surgical Oncology |
| ISSN: | 1534-4681 1068-9265 |
| DOI: | 10.1245/s10434-020-08389-7 |
| Popis: | Background The significance of perineural (PNI), lymphatic (LI) and venous invasion (VI) in gastric cancer patients who have received neoadjuvant chemotherapy is unclear. The aim of this study is to determine the incidence and prognostic significance of LI, VI and PNI in these patients. Patients and Methods Consecutive patients treated with neoadjuvant chemotherapy followed by gastrectomy with D2 lymphadenectomy were reviewed. Presence of LI, VI and PNI was recorded and correlated with clinical outcomes. Results A total of 243 patients underwent gastrectomy after neoadjuvant therapy for gastric adenocarcinoma. LI was identified in 129 (53%), VI in 107 (44%) and PNI in 116 (48%) of patients. Presence of LI (HR, 2.95, CI 1.91–4.56), VI (HR, 2.66, CI 1.78–3.98) and PNI (HR, 3.85, CI 2.49–5.95) was associated with poorer survival (all p Conclusions LI, VI and PNI are associated with poorer survival, with PNI having prognostic significance independent of lymph node status. These factors may be useful for further prognostication, in particular when multiple factors are present, and appear especially useful for prognostic stratification in patients with no nodal involvement. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink