People living with undiagnosed HIV infection and a low CD4 count: Estimates from surveillance data, Italy, 2012 to 2014
| Autor: | Regine, Vincenza, Dorrucci, Maria, Pezzotti, Patrizio, Mammone, Alessia, Quinten, Chantal, Pharris, Anastasia, Suligoi, Barbara, Di Giacomo, Manuela, Faggioni, Viviana, Scancella, Luigi, Locuratolo, Francesco, Cauzillo, Gabriella, Mignuoli, Anna Domenica, Chirico, Daniele Giuseppe, Borgia, Guglielmo, Massimiliani, Erika, Gallo, Tolinda, Braida, Cinzia, Puro, Vincenzo, Scognamiglio, Paola, Icardi, Giancarlo, Lai, Piero Luigi, Gramegna, Maria, Coppola, Liliana, Piatti, Alessandra, Rosa, Annamaria, Cereda, Danilo, Filippetti, Fabio, Prozzo, Alessandra, Pasqualini, Chiara, Mian, Peter, Moling, Oswald, Pagani, Leonardo, Lanzafame, Paolo, Collini, Lucia, Bassetti, Danila, Chironna, Maria, Palmas, Maria Antonietta, Dardanoni, Gabriella, Voller, Fabio, Puglia, Monia, Pecori, Lucia, Tosti, Anna, Papili, Rita, Ruffier, Mauro, Verardo, Marina Giulia, Echarlod, Elisa Francesca, Amoroso, Saveria, Russo, Francesca, Da Re, Filippo |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine Surveillance data Epidemiology HIV diagnosis Prevalence Human immunodeficiency virus (HIV) HIV Infections surveillance data medicine.disease_cause modelling Sexual and Gender Minorities Young Adult 03 medical and health sciences 0302 clinical medicine Virology Humans Medicine 030212 general & internal medicine Heterosexuality Hiv transmission Disease Notification Hiv surveillance business.industry low CD4 count Environmental and Occupational Health Public Health Environmental and Occupational Health virus diseases Middle Aged HIV infection 030112 virology Confidence interval undiagnosed HIV infection CD4 Lymphocyte Count Italy Population Surveillance Epidemiological Monitoring Female Disease prevention Public Health business Research Article Demography |
| Zdroj: | Eurosurveillance |
| Popis: | Background and aims Late HIV diagnosis is associated with onward HIV transmission, higher morbidity, mortality and healthcare costs. In Italy, more than half of people living with HIV were diagnosed late during the last decade, with a CD4 count 3 at diagnosis. We aimed to determine the number and characteristics of people living with undiagnosed HIV infection and low CD4 counts in Italy. Methods: Data on newly reported HIV diagnoses from 2012 –2014 were obtained from the national HIV surveillance system. We used the European Centre for Disease Prevention and Control HIV modelling tool to calculate the undiagnosed prevalence and yearly diagnosed fraction (YDF) in people with low CD4 count. Results: The estimated annual number undiagnosed HIV infections with low CD4 count was on average 6,028 (95% confidence interval (CI): 4,954–8,043) from 2012–2014. In 2014, most of the undiagnosed people with low CD4 count were men (82.8%), a third acquired HIV through sex between men (MSM) (35.0%), and heterosexual transmission (33.4%), respectively. The prevalence of undiagnosed HIV infection was 11.3 (95% CI: 9.3–14.9) per 100,000 residents ranging from 0.7 to 20.8 between Italian regions. Nationally the prevalence rate was 280.4 (95% CI: 173.3–450.2) per 100,000 MSM, 8.3 (95% CI: 4.9–13.6) per 100,000 heterosexual men, and 3.0 (95% CI: 1.4–5.6) per 100,000 women. The YDF was highest among heterosexual women (27.1%; 95% CI: 16.9–45.2%). Conclusions: These findings highlight the importance of improving efforts to identify undiagnosed HIV infections primarily among men, both MSM and heterosexual men. |
| Databáze: | OpenAIRE |
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