Accelerating a paradigm shift: The Common Fund Single Cell Analysis Program
| Autor: | Richard S. Conroy, J M Smith, Yong Yao, Andrea Beckel-Mitchener, Ananda L. Roy, James M. Anderson, Elizabeth L. Wilder |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Multidisciplinary Computer science Sequence Analysis RNA Computational Biology High-Throughput Nucleotide Sequencing Reviews Disease Review Cellular level Data science United States 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Single-cell analysis National Institutes of Health (U.S.) Paradigm shift Common fund Humans Single-Cell Analysis SciAdv reviews Molecular Biology 030217 neurology & neurosurgery |
| Zdroj: | Science Advances |
| ISSN: | 2375-2548 |
| Popis: | The Single Cell Analysis Program catalyzed technologies leading to explore human tissue heterogeneity at the cellular level. It has become exceedingly important to understand the precise molecular profiles of the nearly 40 trillion cells in an adult human because of their role in determining health, disease, and therapeutic outcome. The National Institutes of Health (NIH) Common Fund–supported Single Cell Analysis Program (SCAP) was designed to address this challenge. In this review, we outline the original program goals and provide a perspective on the impact of the program as a catalyst for exploration of heterogeneity of human tissues at the cellular level. We believe that the technological advances in single-cell RNA sequencing and multiplexed imaging combined with computational methods made by this program will undoubtedly have an impact on broad and robust applications of single-cell analyses in both health and disease research. |
| Databáze: | OpenAIRE |
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