Caregiver burden and its related factors in advanced Parkinson's disease: data from the PREDICT study

Autor: Leonardo Lopiano, Paolo Solla, Mariachiara Sensi, Giovanni Defazio, Rocco Quatrale, Nicola Tambasco, Anna Maria Costanzo, Pietro Marano, Angelo Antonini, Umberto di Luzio Paparatti, Francesco E. Pontieri, Nicola Modugno, Alessandro Tessitore, Gabriella Melzi, Margherita Canesi, Giuliana Gualberti, Anna Latorre
Přispěvatelé: Tessitore, A., Marano, P., Modugno, N., Pontieri, F. E., Tambasco, N., Canesi, M., Latorre, A., Lopiano, L., Sensi, M., Quatrale, R., Solla, P., Defazio, G., Melzi, G., Costanzo, A. M., Gualberti, G., di Luzio Paparatti, U., Antonini, A.
Rok vydání: 2017
Předmět:
Male
Neurology
Parkinson's disease
Apomorphine
Cross-sectional study
Socioeconomic Factor
Antiparkinson Agents
Levodopa
0302 clinical medicine
Quality of life
Cost of Illness
Drug Combination
advanced parkinson’s disease
Surveys and Questionnaires
80 and over
Surveys and Questionnaire
030212 general & internal medicine
Aged
80 and over
Advanced Parkinson’s disease
Caregiver burden
Intestinal infusion
Levodopa/carbidopa
Neurology (clinical)
Carbidopa
Parkinson Disease
Middle Aged
3. Good health
Distress
Drug Combinations
Treatment Outcome
Caregivers
Italy
Patient Satisfaction
Antiparkinson Agent
Female
medicine.drug
Human
medicine.medical_specialty
Aged
Cross-Sectional Studies
Family
Humans
Quality of Life
Socioeconomic Factors
levodopa/carbidopa
03 medical and health sciences
Patient satisfaction
medicine
Cross-Sectional Studie
caregiver burden
business.industry
intestinal infusion
quality of life
Correction
medicine.disease
Caregiver
Physical therapy
business
030217 neurology & neurosurgery
Zdroj: Journal of Neurology
ISSN: 1432-1459
Popis: Introduction: Caring for a person with Parkinson’s disease (PD) is associated with an increased risk of psychiatric morbidity and persistent distress. The objective of this study was to describe the burden and the related factors of caregivers of advanced PD (APD) patients either treated with continuous dopaminergic delivery systems or standard therapy. Methods: This cross-sectional, epidemiologic study conducted in 13 Italian sites enrolled PD patients treated with continuous dopaminergic delivering systems [either levodopa/carbidopa intestinal gel (LCIG) infusion or continuous subcutaneous apomorphine infusion (CSAI)] or continuation of standard of care (SOC) with a caregiver. Patient quality of life (QoL) and caregiver burden were assessed using the Parkinson’s Disease Questionnaire (PDQ-8) and Zarit Burden Inventory (ZBI), respectively. Results: 126 patients (mean age 69.3 ± 8years) and their caregivers (mean age 57.9 ± 12.9) were enrolled. Most caregivers were spouses. Fifty-three patients were treated with LCIG, 19 with CSAI, and 54 with SOC. Mean ZBI scores were 29.6 ± 14.4 for LCIG, 35.8 ± 20.2 for CSAI, and 31.4 ± 16.0 for SOC. Caregivers of LCIG, CSAI, and SOC patients showed no burden or mild/moderate burden in 74, 53, and 63% of the cases, respectively. Mean PDQ-8 scores were 11.25 ± 5.67, 11.26 ± 5.55, and 14.22 ± 6.51 in LCIG, CSAI, and SOC patients. Neurologists considered patients “very much or much improved” in 89, 58, and 13% of the LCIG, CSAI, and SOC groups using the Clinical Global Impression–Global Improvement Scale. Predictors significantly associated with caregiver burden were patients and caregivers’ judgment of QoL and caregivers’ need to change work. Conclusions: Caregiver burden showed a tendency to be lower when patients are treated with LCIG than with CSAI or SOC.
Databáze: OpenAIRE
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