Deep phenotyping of 34,128 adult patients hospitalised with COVID-19 in an international network study
| Autor: | María Aragón, Peter R. Rijnbeek, Jennifer C E Lane, Seok Young Song, Alexander Davydov, Kristin Kostka, Asieh Golozar, Maria Tereza Fernandes Abrahão, Christian G. Reich, Nigam H. Shah, Haini Wen, Lin Zhang, Daniel R. Morales, Belay Birlie Yimer, Oleg Zhuk, Thomas Falconer, Aedín C. Culhane, Carlos Areia, Juan M. Banda, Jimyung Park, Jill Hardin, Andrew E. Williams, Rupa Makadia, Weihua Gao, Fredrik Nyberg, George Hripcsak, Yonghua Jing, Hokyun Jeon, Albert Prats-Uribe, Michael E. Matheny, Matthew E. Spotnitz, Thamir M. Alshammari, Osaid Alser, Rae Woong Park, Martijn J. Schuemie, Jose D. Posada, Paras P. Mehta, Seng Chan You, Salvatore Volpe, Gowtham A. Rao, Hamed Abedtash, Hyejin Lee, Chi Young Jung, Benjamin Skov Kaas-Hansen, Sergio Fernandez-Bertolin, Vojtech Huser, Kristine E. Lynch, Yeunsook Rho, Anna Ostropolets, Patrick B. Ryan, Amanda Alberga, Seamus Kent, Jaehyeong Cho, Spyros Kolovos, Azza Shoaibi, Marc A. Suchard, Heba Alghoul, Yeesuk Kim, Denys Kaduk, David Vizcaya, Frank J. DeFalco, Joel N. Swerdel, Karthik Natarajan, Scott L. DuVall, Daniel Prieto-Alhambra, Lisa M. Schilling, Talita Duarte-Salles, Edward Burn, Anthony G. Sena |
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| Přispěvatelé: | Medical Informatics |
| Rok vydání: | 2020 |
| Předmět: |
Male
020205 medical informatics characteristics General Physics and Astronomy Comorbidity 02 engineering and technology Cohort Studies 0302 clinical medicine Epidemiology Pandemic 80 and over Prevalence 0202 electrical engineering electronic engineering information engineering Viral 030212 general & internal medicine Young adult lcsh:Science Aged 80 and over Multidisciplinary Age Factors Middle Aged 3. Good health Hospitalization Infectious Diseases Pneumonia & Influenza Female Coronavirus Infections Human Cohort study Adult medicine.medical_specialty Coronavirus disease 2019 (COVID-19) phenotype Science Pneumonia Viral MEDLINE and over comorbidities Article General Biochemistry Genetics and Molecular Biology Young Adult 03 medical and health sciences Sex Factors Influenza Human Republic of Korea network study medicine Humans Pandemics Aged influence International network business.industry COVID-19 Pneumonia General Chemistry medicine.disease Influenza United States Emerging Infectious Diseases Spain lcsh:Q business Demography |
| Zdroj: | Burn, E, You, S C, Sena, A G, Kostka, K, Abedtash, H, Abrahão, M T F, Alberga, A, Alghoul, H, Alser, O, Alshammari, T M, Aragon, M, Areia, C, Banda, J M, Cho, J, Culhane, A C, Davydov, A, DeFalco, F J, Duarte-Salles, T, DuVall, S, Falconer, T, Fernandez-Bertolin, S, Gao, W, Golozar, A, Hardin, J, Hripcsak, G, Huser, V, Jeon, H, Jing, Y, Jung, C Y, Kaas-Hansen, B S, Kaduk, D, Kent, S, Kim, Y, Kolovos, S, Lane, J C E, Lee, H, Lynch, K E, Makadia, R, Matheny, M E, Mehta, P P, Morales, D R, Natarajan, K, Nyberg, F, Ostropolets, A, Park, R W, Park, J, Posada, J D, Prats-Uribe, A, Rao, G, Reich, C, Rho, Y, Rijnbeek, P, Schilling, L M, Schuemie, M, Shah, N H, Shoaibi, A, Song, S, Spotnitz, M, Suchard, M A, Swerdel, J N, Vizcaya, D, Volpe, S, Wen, H, Williams, A E, Yimer, B B, Zhang, L, Zhuk, O, Prieto-Alhambra, D & Ryan, P 2020, ' Deep phenotyping of 34,128 adult patients hospitalised with COVID-19 in an international network study ', Nature Communications, vol. 11, no. 1, 5009 . https://doi.org/10.1038/s41467-020-18849-z medRxiv article-version (status) pre article-version (number) 1 Nature Communications Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020) Nature communications, vol 11, iss 1 Nature Communications, 11(1):5009. Nature Publishing Group Burn, E, You, S C, Sena, A G, Kostka, K, Abedtash, H, Abrahão, M T F, Alberga, A, Alghoul, H, Alser, O, Alshammari, T M, Aragon, M, Areia, C, Banda, J M, Cho, J, Culhane, A C, Davydov, A, DeFalco, F J, Duarte-Salles, T, DuVall, S, Falconer, T, Fernandez-Bertolin, S, Gao, W, Golozar, A, Hardin, J, Hripcsak, G, Huser, V, Jeon, H, Jing, Y, Jung, C Y, Kaas-Hansen, B S, Kaduk, D, Kent, S, Kim, Y, Kolovos, S, Lane, J C E, Lee, H, Lynch, K E, Makadia, R, Matheny, M E, Mehta, P P, Morales, D R, Natarajan, K, Nyberg, F, Ostropolets, A, Park, R W, Park, J, Posada, J D, Prats-Uribe, A, Rao, G, Reich, C, Rho, Y, Rijnbeek, P, Schilling, L M, Schuemie, M, Shah, N H, Shoaibi, A, Song, S, Spotnitz, M, Suchard, M A, Swerdel, J N, Vizcaya, D, Volpe, S, Wen, H, Williams, A E, Yimer, B B, Zhang, L, Zhuk, O, Prieto-Alhambra, D & Ryan, P 2020, ' Deep phenotyping of 34,128 adult patients hospitalised with COVID-19 in an international network study ', Nature Communications, vol. 11, no. 1, pp. 5009 . https://doi.org/10.1038/s41467-020-18849-z |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-020-18849-z |
| Popis: | Background To better understand the profile of individuals with severe coronavirus disease 2019 (COVID-19), we characterised individuals hospitalised with COVID-19 and compared them to individuals previously hospitalised with influenza. Methods We report the characteristics (demographics, prior conditions and medication use) of patients hospitalised with COVID-19 between December 2019 and April 2020 in the US (Columbia University Irving Medical Center [CUIMC], STAnford Medicine Research data Repository [STARR-OMOP], and the Department of Veterans Affairs [VA OMOP]) and Health Insurance Review & Assessment [HIRA] of South Korea. Patients hospitalised with COVID-19 were compared with patients previously hospitalised with influenza in 2014–19. Results 6,806 (US: 1,634, South Korea: 5,172) individuals hospitalised with COVID-19 were included. Patients in the US were majority male (VA OMOP: 94%, STARR-OMOP: 57%, CUIMC: 52%), but were majority female in HIRA (56%). Age profiles varied across data sources. Prevalence of asthma ranged from 7% to 14%, diabetes from 18% to 43%, and hypertensive disorder from 22% to 70% across data sources, while between 9% and 39% were taking drugs acting on the renin-angiotensin system in the 30 days prior to their hospitalisation. Compared to 52,422 individuals hospitalised with influenza, patients admitted with COVID-19 were more likely male, younger, and, in the US, had fewer comorbidities and lower medication use. Conclusions Rates of comorbidities and medication use are high among individuals hospitalised with COVID-19. However, COVID-19 patients are more likely to be male and appear to be younger and, in the US, generally healthier than those typically admitted with influenza. |
| Databáze: | OpenAIRE |
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