First-Line Treatment with a Cyclin-Dependent Kinase 4/6 Inhibitor Plus an Aromatase Inhibitor for Metastatic Breast Cancer in Alberta
| Autor: | Carla P Amaro, Atul Batra, Sasha M. Lupichuk |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Oncology
medicine.medical_specialty real-world Canada Multivariate analysis palbociclib Receptor ErbB-2 medicine.drug_class medicine.medical_treatment Population Breast Neoplasms Palbociclib Article Alberta median time to progression on second-line treatment Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Neoplasm Metastasis ribociclib education RC254-282 education.field_of_study Chemotherapy Aromatase inhibitor biology Aromatase Inhibitors Cyclin-dependent kinase 4 business.industry Cyclin-Dependent Kinase 4 Neoplasms. Tumors. Oncology. Including cancer and carcinogens Cyclin-Dependent Kinase 6 Middle Aged medicine.disease Metastatic breast cancer biology.protein Hormonal therapy Female metastatic breast cancer business |
| Zdroj: | Current Oncology, Vol 28, Iss 209, Pp 2270-2280 (2021) Current Oncology Volume 28 Issue 3 Pages 209-2280 |
| ISSN: | 1198-0052 1718-7729 |
| Popis: | In this analysis, we describe population-based outcomes for first-line treatment with a cyclin-dependent kinase 4/6 inhibitor (CDK4/6i) combined with an aromatase inhibitor (AI). All patients who were prescribed CDK4/6i + AI from January 2016 through June 2019 were included. Patient demographics, tumour and treatment characteristics were collected and described. Survival distributions were estimated using the Kaplan–Meier method. Multivariate analysis (MVA) was constructed to examine associations between potentially prognostic clinical variables and progression-free survival (PFS). In total, 316 patients were included. The median age was 61 years. After a median follow-up of 28.1 months, the median PFS was 37.9 months (95% CI, 26.7–NR). In the MVA, PR-negative tumour (HR, 2.37 95% CI, 1.45–3.88 p = 0.001) and CDK4/6i dose reduction (HR, 1.51 95% CI, 1.06–2.16 p = 0.022) predicted worse PFS. Median overall survival (OS) was not reached. The 30-month and 36-month OS rates were 74% and 68%, respectively. Of patients who progressed, 89% received second-line treatment. Median time to progression on second-line chemotherapy was 9.0 (5.8–17.6) months, and median time to progression on second-line hormonal therapy +/− targeted agent was 4.0 (3.4–8.6) months (p = 0.012). CDK4/6i + AI as first-line treatment for HR-positive, HER2-negative MBC in Alberta is justified based on favourable PFS and early OS outcomes. |
| Databáze: | OpenAIRE |
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