Changes in the neutrophil to lymphocyte ratio as predictors of outcome in pediatric patients with central nervous system tumors undergoing surgical resection

Autor:	Arnoldo Aquino-Gálvez, Manuel-De-Jesús Castillejos-López, Laura M Hernández-Regino, Daniel Martínez-Rodríguez, Armando de Uña-Flores, Citlaltepetl Salinas-Lara, Luz María Torres-Espíndola, Al Flores-Bustamante, Patricia Sierra-Vargas, Marta Zapata-Tarrés
Rok vydání:	2022
Předmět:	Surgical resection Cancer Research Prognostic factor medicine.medical_specialty Neutrophils Central nervous system Kaplan-Meier Estimate Gastroenterology Central Nervous System Neoplasms Interquartile range Internal medicine Genetics Humans Medicine Clinical significance Lymphocytes Neutrophil to lymphocyte ratio Child Survival analysis Retrospective Studies business.industry Retrospective cohort study General Medicine Prognosis medicine.anatomical_structure Oncology business
Zdroj:	Cancer Biomarkers. 33:291-298
ISSN:	1875-8592 1574-0153
DOI:	10.3233/cbm-200857
Popis:	BACKGROUND: Changes in neutrophil to lymphocyte ratio (ΔNLR) have been used as a clinical tool for stratification and prognosis of patients with solid tumors, there is scarce evidence of their clinical relevance in patients with tumors of the central nervous system who have also undergone surgical resection. OBJECTIVE: Determine if (ΔNLR) are associated with poor response to treatment and worse prognosis in pediatric patients with central nervous system tumors (CNST) who underwent surgical resection. METHODS: We performed a retrospective cohort study; demographic, clinical, and hematological variables were evaluated, Kaplan-Meier survival curves and Cox proportional hazards regression model were performed to evaluate prognosis. RESULTS: The ΔNLR cutoff value obtained through the third interquartile range was 4.30; The probability of survival and complete response to treatment was different between patients with high ΔNLR when compared to patients with low ΔNLR (p= 0.013, p=≪ 0.001, respectively). A high ΔNLR behaved as an independent predictor of worse Overall Survival (HR 2,297; 95% CI: 1,075–4.908, p= 0.032). CONCLUSION: An elevated ΔNLR was a predictor of poor response to treatment and a prognostic factor for worse Overall Survival in pediatric patients with CNST undergoing surgical resection.
Databáze:	OpenAIRE
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