Poly(ADP-Ribose)-Dependent Ubiquitination and its Clinical Implications
| Autor: | Christina A. Vivelo, Anthony K.L. Leung, Vinay Ayyappan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Pharmacology
Poly Adenosine Diphosphate Ribose biology DNA Repair DNA repair Neurodegeneration Ubiquitination Structural integrity Protein degradation medicine.disease Biochemistry Article Protein Structure Secondary Cell biology chemistry.chemical_compound Ubiquitin chemistry Transcription (biology) Ribose biology.protein medicine Posttranslational modification Animals Humans |
| Zdroj: | Biochem Pharmacol |
| Popis: | ADP-ribosylation-the addition of one or multiple ADP-ribose units onto proteins-is a therapeutically important post-translational modification implicated in cancer, neurodegeneration, and infectious diseases. The protein modification regulates a broad range of biological processes, including DNA repair, transcription, RNA metabolism, and the structural integrity of nonmembranous structures. The polymeric form of ADP-ribose, poly(ADP-ribose), was recently identified as a signal for triggering protein degradation through the ubiquitin-proteasome system. Using informatics analyses, we found that these ubiquitinated substrates tend to be low abundance proteins, which may serve as rate-limiting factors within signaling networks or metabolic processes. In this review, we summarize the current literature on poly(ADP-ribose)-dependent ubiquitination (PARdU) regarding its biological mechanisms, substrates, and relevance to diseases. |
| Databáze: | OpenAIRE |
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