Fucoxanthin increases lifespan of Drosophila melanogaster and Caenorhabditis elegans
| Autor: | Ekaterina Lashmanova, Elena Marusich, Alex Zhavoronkov, Sergey V. Leonov, Alex Melerzanov, Ekaterina Proshkina, Alexey Moskalev, Svetlana Zhikrivetskaya, Oksana Shevchenko |
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| Rok vydání: | 2015 |
| Předmět: |
Male
media_common.quotation_subject Longevity Biology Motor Activity Xanthophylls medicine.disease_cause chemistry.chemical_compound Paraquat medicine Fucoxanthin Animals Caenorhabditis elegans Carotenoid media_common Pharmacology chemistry.chemical_classification fungi biology.organism_classification Fecundity Carotenoids Oxidative Stress Drosophila melanogaster chemistry Biochemistry Female Oxidative stress |
| Zdroj: | Pharmacological research. 100 |
| ISSN: | 1096-1186 |
| Popis: | The pharmacological activation of stress-defense mechanisms is one of the perspective ways to increase human lifespan. The goal of the present study was to study the effects on lifespan of Drosophila melanogaster and Caenorhabditis elegans of two carotenoids: s-carotene and fucoxanthin, which are bioactive natural substances in human diet. In addition, the effects of carotenoids on the flies survival were studied under stress conditions, including starvation, thermal stress (35°C), oxidative stress (20 mM paraquat), as well as locomotor activity, fecundity, and genes expression level. Our results demonstrated lifespan extension of flies by both carotenoids. However, the positive effects on the lifespan of C. elegans were revealed only for fucoxanthin. In presence of carotenoids decreased flies' fecundity, increased spontaneous locomotor activity and resistance to oxidative stress were detected. |
| Databáze: | OpenAIRE |
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