Connexins and their channels in cell growth and cell death
| Autor: | Tom Henkens, Peggy Papeleu, Tamara Vanhaecke, Vera Rogiers, Mathieu Vinken, Sarah Snykers |
|---|---|
| Přispěvatelé: | Toxicology, Dermato-cosmetology and Pharmacognosy |
| Rok vydání: | 2006 |
| Předmět: |
connexin
hemichannel Cell Death Cell growth Gap junction Gap Junctions Cellular homeostasis Connexin Cell Communication Cell Growth Processes Cell Biology Cell cycle Biology Connexins Connexon Cell biology gap junction Cellular communication cell proliferation Neoplasms Animals Homeostasis Intracellular |
| Zdroj: | Vrije Universiteit Brussel |
| ISSN: | 0898-6568 |
| DOI: | 10.1016/j.cellsig.2005.08.012 |
| Popis: | Direct communication between cells, mediated by gap junctions, is nowadays considered as an indispensable mechanism in the maintenance of cellular homeostasis. In fact, gap junctional intercellular communication is actively involved in virtually all aspects of the cellular life cycle, ranging from cell growth to cell death. For a long time, it was believed that this was merely a result of the capacity of gap junctions to control the direct intercellular exchange of essential cellular messengers. However, recent data show that the picture is more complicated than initially thought, as structural precursors of gap junctions, connexins and gap junction hemichannels, can affect the cellular homeostatic balance independently of gap junctional intercellular communication. In this paper, we summarize the current knowledge concerning the roles of connexins and their channels in the control of cellular homeostasis, with the emphasis on cell growth and cell death. We also briefly discuss the role of gap junctional intercellular communication in carcinogenesis and the potential use of connexins as tools for cancer therapy. |
| Databáze: | OpenAIRE |
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