Cardiac dysrhythmias in the conscious dog after surgically induced autonomic imbalance
| Autor: | H. Kurt Jacobs, William H. Wehrmacher, Walter C. Randall, Michael P. Kaye, Gilbert R. Hageman, David E. Euler |
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| Rok vydání: | 1976 |
| Předmět: |
Male
medicine.medical_specialty Sympathetic Nervous System Refractory period Purkinje fibers Heart Ventricles Central nervous system Synaptic Transmission Electrocardiography Dogs Postoperative Complications Heart Conduction System Tachycardia Internal medicine medicine Animals Heart Atria Sinoatrial Node Denervation business.industry Arrhythmias Cardiac Myocardial Contraction Electric Stimulation Nerve Regeneration medicine.anatomical_structure Cardiac nerve Anesthesia Autonomic imbalance Atrioventricular Node Exercise Test cardiovascular system Cardiology Autonomic Fibers Postganglionic Female Electrical conduction system of the heart Cardiology and Cardiovascular Medicine business Reinnervation |
| Zdroj: | The American Journal of Cardiology. 38:178-183 |
| ISSN: | 0002-9149 |
| DOI: | 10.1016/0002-9149(76)90146-6 |
| Popis: | The ventrolateral cardiac nerve in the dog is a primary branch of the left sympathetics and represents a direct neural link between the central nervous system and the heart. Its electric excitation elicits characteristic shifts in pacemaker and tachydysrhythmias related to its explicit innervation of the inferior atrial, atrioventricular (A-V) junctional and ventricular tissues. Total denervation of the canine heart, sparing the ventrolateral cardiac nerve, produced a long-term model in which only these portions of the heart retained their sympathetic innervation. The trained unanesthetized model dog was subjected to severe exercise in order to determine the effects of elevated levels of sympathetic tone upon these important regions of the conduction system. Reproducible tachydysrhythmias were elicited in all six animals completing the regimen of periodic testingover a period of 136 to 378 days after operation. The abnormal rhythms consisted of shifting cardiac pacemakers and supraventricular A-V junctional and ventricular tachycardias with frequent premature systoles. Comparable abnormalities were not observed in a similarly tested sham-operated animal or in dogs with a totally denervated heart. The exercise-induced dysrhythmias gradually disappeared with time, presumably in relation to autonomic reinnervation of the heart. The characteristic patterns of dysrhythmia are explainable on the basis of anatomic distribution of the ventrolateral cardiac nerve and upon its presumed influence upon Purkinje fiber and A-V nodal automaticity and temporal dispersion of refractoriness in myocardial tissues. |
| Databáze: | OpenAIRE |
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