Cancer in the offspring of radiation workers: an investigation of employment timing and a reanalysis using updated dose information
| Autor: | Tom Sorahan, Colin R. Muirhead, Leo Kinlen, Mark P. Little, Richard Haylock, Gerald M. Kendall, R J Lancashire, Gerald Draper, Kathryn J. Bunch, M A English |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Employment Male Cancer Research medicine.medical_specialty Neoplasms Radiation-Induced Time Factors Adolescent Epidemiology Offspring occupational exposures Disease Occupational medicine Nuclear Reactors immune system diseases Occupational Exposure hemic and lymphatic diseases medicine Humans childhood cancer Child Radiometry Leukemia Radiation-Induced business.industry Lymphoma Non-Hodgkin Incidence (epidemiology) Case-control study Cancer Dose-Response Relationship Radiation medicine.disease Surgery radiation Paternal Exposure Oncology El Niño Case-Control Studies Female business Demography |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| Popis: | An earlier case-control study found no evidence of paternal preconceptional irradiation (PPI) as a cause of childhood leukaemia and non-Hodgkin's lymphoma (LNHL). Although fathers of children with LNHL were more likely to have been radiation workers, the risk was most marked in those with doses below the level of detection. The timing of paternal employment as a radiation worker has now been examined. The previously reported elevated risk of LNHL in the children of male radiation workers was limited to those whose fathers were still radiation workers at conception or whose employment also continued until diagnosis. Children whose fathers stopped radiation work prior to their conception were found to have no excess risk of LNHL. It was not possible to distinguish between the risks associated with paternal radiation work at conception and at the time of diagnosis. A reanalysis of the original study hypothesis incorporating updated dosimetric information gave similar results to those obtained previously. In particular, the risks of LNHL did not show an association with radiation doses received by the father before conception. It seems likely that the increased risk of LNHL among the children of male radiation workers is associated with an increased exposure to some infective agent consequent on high levels of population mixing. |
| Databáze: | OpenAIRE |
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