Epigenetic control of hematopoietic stem cell aging the case of Ezh2

Autor:	de Haan, Gerald, Gerrits, Alice, Kanz, L, Weisel, KC, Dick, JE, Fibbe, WE
Přispěvatelé:	Stem Cell Aging Leukemia and Lymphoma (SALL)
Rok vydání:	2007
Předmět:	Senescence senescence LONG-TERM Stem cell theory of aging GENETIC GENOMICS Polycomb-Group Proteins macromolecular substances Biology MOUSE Models Biological General Biochemistry Genetics and Molecular Biology CAPACITY Epigenesis Genetic Histones History and Philosophy of Science stem cells medicine Polycomb-group proteins Animals Humans Enhancer of Zeste Homolog 2 Protein Epigenetics Ezh2 Cellular Senescence LIFE-SPAN Genetics TRANSPLANTATION General Neuroscience aging Polycomb Repressive Complex 2 Hematopoietic stem cell Genomics Hematopoietic Stem Cells Chromatin Cell biology Transplantation DNA-Binding Proteins Repressor Proteins Haematopoiesis SELF-RENEWAL MICE medicine.anatomical_structure MARROW Gene Expression Regulation Stem cell polycomb Transcription Factors
Zdroj:	HEMATOPOIETIC STEM CELLS VI, 233-239 STARTPAGE=233;ENDPAGE=239;TITLE=HEMATOPOIETIC STEM CELLS VI
ISSN:	0077-8923
Popis:	Hematopoietic stem cells have potent, but not unlimited, selfrenewal potential. The mechanisms that restrict selfrenewal are likely to play a role during aging. Recent data suggest that the regulation of histone modifications by Polycomb group genes may be of crucial relevance to balance selfrenewal and aging. We provide evidence for the involvement of one of these Polycomb group genes, Ezh2, in aging of the hematopoietic stem cell system.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19441076070d68f423641c57c7f84169 https://pubmed.ncbi.nlm.nih.gov/17332078 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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