CONTRIBUTION OF FRONTAL CEREBRAL BLOOD FLOW MEASURED BY 99mTc-BICISATE SPECT AND EXECUTIVE FUNCTION DEFICITS TO PREDICTING TREATMENT OUTCOME IN ALCOHOL-DEPENDENT PATIENTS
| Autor: | Paul Verbanck, Rita Sferrazza, Martial Van der Linden, Michel Verhas, Jacques Paternot, Isidore Pelc, Catherine Hanak, Xavier Noël |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Temperance Drug/alcohol abstinence medicine Humans Memory disorder Psychiatry Episodic memory Tomography Emission-Computed Single-Photon Analysis of Variance Memory Disorders California Verbal Learning Test Working memory Brain Technetium General Medicine Medial frontal gyrus Middle Aged medicine.disease Alcoholism medicine.anatomical_structure Treatment Outcome Cerebral blood flow Anesthesia Cerebrovascular Circulation Female Psychology Executive dysfunction |
| Popis: | Aim: To determine whether inhibition and working memory deficits, and reduced regional cerebral blood flow (rCBF) (previously shown to be related), measured at the end of a detoxification programme, predict alcoholic relapse 2 months later. Methods: Twenty uncomplicated alcoholic inpatients were investigated at the end of detoxification, at least 7 days since the last dose of diazepam, and a mean of 18.8 days since the last drink. Their performance was assessed on the inhibition (Hayling) test, wor king memory (Alpha-span task), episodic memory (California Verbal Learning Test) and abstract reasoning (Progressive Matrices). Fron tal CBF was assessed at the same time with a semiquantitative 99m Tc-Bicisate SPECT procedure. Patients were contacted 2 months later. Patients who abstained (n = 9) did not differ from those who relapsed ( n = 11) on age, gender, smoking, duration of alcohol misuse, number of previous detoxifications, amount of ethanol consumed the month prior to admission to the detoxification programme, st ate anxiety, trait anxiety, or depression. Results: Relapsed subjects had shown a lower uptake of 99mTc-Bicisate in the bilateral medial frontal gyrus (n = 9; mean ratio ± SD = 0.69 ± 0.006) than abstainers ( n = 11; 0.85 ± 0.19), and poorer performance on the Alpha-span task and the Hayling test. The other tests were not different. Conclusions: Inhibition and working memory deficits, associated with low levels of CBF in the medial frontal gyrus, are related to the difficulty of maintaining short-term abstinence from alcohol. |
| Databáze: | OpenAIRE |
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