A new liver functional study using Tc-99m DTPA-galactosyl human serum albumin: Evaluation of the validity of several functional parameters
| Autor: | Takao Ainoda, Yoshioki Yoda, Takao Arai, Kiyoshi Koizumi, Guio Uchiyama |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
Liver Cirrhosis Male medicine.medical_specialty Carcinoma Hepatocellular Cirrhosis Technetium Tc 99m Aggregated Albumin Gastroenterology chemistry.chemical_compound Internal medicine Carcinoma Humans Medicine Radiology Nuclear Medicine and imaging Radionuclide Imaging Technetium Tc 99m Pentetate Aged business.industry Liver Neoplasms General Medicine Middle Aged medicine.disease Human serum albumin Endocrinology chemistry Hepatocellular carcinoma Female Liver function business Indocyanine green medicine.drug |
| Zdroj: | Annals of Nuclear Medicine. 6:83-87 |
| ISSN: | 1864-6433 0914-7187 |
| DOI: | 10.1007/bf03164647 |
| Popis: | Several parameters calculated with a new functional imaging agent for the liver, Tc-99m DTPA-galactosyl human serum albumin, were evaluated in 9 patients with liver cirrhosis, one with hepatocellular carcinoma, and five with both liver cirrhosis and hepatocellular carcinoma. LU3, which represents the cumulative uptake of the tracer from 3 to 4 minutes after injection, showed a strong correlation (r = 0.858, p = 0.0001) with LHL15, which represents the count ratio for the liver to sum for the liver and heart 15 minutes after injection of the tracer. It also showed a strong correlation (r = -0.896, p = 0.0001) with the indocyanine green retention rate (ICGR15). Regional ICGR15 is therefore calculable from the regional LU3. GSAR15, which represents the radioactivity of the tracer retained in the blood 15 minutes after injection, showed a strong correlation (r = 0.878, p = 0.0001) with HH15, which represents the count ratio for the heart 15 minutes after injection of the tracer divided by the count for the heart 3 minutes after injection. In conclusion, LU3 and GSAR15 are interesting and promising parameters for assessing liver function. |
| Databáze: | OpenAIRE |
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