Chorionic gonadotropin alleviates thioglycollate-induced peritonitis by affecting macrophage function

Autor: Pieter J. M. Leenen, Hui Wan, Nico van Rooijen, Robbert Benner, Nisar Ahmed Khan, Marjan A. Versnel, Jojanneke M. C. Coppens, Cornelia G van Helden-Meeuwsen, Rebecca C. M. Kiekens
Přispěvatelé: Molecular cell biology and Immunology, CCA - Immuno-pathogenesis, Immunology
Rok vydání: 2009
Předmět:
medicine.medical_specialty
endocrine system
Cell Survival
medicine.drug_class
medicine.medical_treatment
Immunology
Peritonitis
CCL3
Inflammation
Chorionic Gonadotropin
Monocytes
Proinflammatory cytokine
Mice
SDG 3 - Good Health and Well-being
Internal medicine
Immune Tolerance
medicine
Animals
Immunology and Allergy
Macrophage
Receptors
Cytokine
Cells
Cultured
reproductive and urinary physiology
NOD mice
Interleukin-6
Tumor Necrosis Factor-alpha
urogenital system
business.industry
Macrophages
hemic and immune systems
Cell Biology
medicine.disease
Mice
Inbred C57BL
Disease Models
Animal
Cytokine
Endocrinology
Cytoprotection
Thioglycolates
Liposomes
Cytokines
Female
Inflammation Mediators
medicine.symptom
Gonadotropin
business
Immunosuppressive Agents
hormones
hormone substitutes
and hormone antagonists
Zdroj: Journal of Leukocyte Biology, 86(2), 361-370. FASEB
Wan, H, Coppens, J M, van Helden-Meeuwsen, C G, Leenen, P J, van Rooijen, N, Khan, N A, Kiekens, R C M, Benner, R & Versnel, M A 2009, ' Chorionic gonadotropin alleviates thioglycollate-induced peritonitis by affecting macrophage function ', Journal of Leukocyte Biology, vol. 86, no. 2, pp. 361-370 . https://doi.org/10.1189/jlb.0208126
Journal of Leukocyte Biology, 86(2), 361-370. John Wiley & Sons Inc.
ISSN: 0741-5400
DOI: 10.1189/jlb.0208126
Popis: hCG contributes to the controlled inflammatory state of pregnancy by regulating MΦ pro-inflammatory function. Human chorionic gonadotrophin (hCG) is a hormone produced during pregnancy and present at the implantation site and in the maternal blood. Pregnancy has been proposed to represent a controlled state of inflammation at an early stage at the implantation site and later, systemically extended to the maternal circulation. Earlier, we reported that hCG can inhibit the development of diabetes in NOD mice and LPS-induced septic shock in a murine model. We hypothesize that hCG can contribute to the reduction of inflammation by modifying Mϕ function. Here, the TG-induced peritonitis model for inflammation was used to investigate the effect of hCG on cytokine production and cell recruitment in vivo. hCG pretreatment in TG-induced peritonitis increased the number of peritoneal cells, especially PMN and monocytes, compared with mice injected with TG only. This increased cell number was partially explained by increased cell survival induced by hCG. Despite the cellular infiltrate, hCG pretreatment decreased i.p. TNF-α, IL-6, PTX3, CCL3, and CCL5 levels. By depleting peritoneal resident Mϕ using clodronate liposomes prior to the application of hCG and the TG trigger, we established that Mϕ are the main responsive cells to hCG, as the suppressed TNF-α and IL-6 production and increased PMN influx are abolished in their absence. Together, these data suggest that hCG contributes to the controlled inflammatory state of pregnancy by regulating Mϕ proinflammatory function.
Databáze: OpenAIRE
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