Exocrine pancreas insufficiency in chronic pancreatitis – Risk factors and associations with complications. A multicentre study of 1869 patients

Autor: Friedemann Erchinger, Trond Engjom, Georg Dimcevski, Asbjørn M. Drewes, Søren Schou Olesen, Miroslav Vujasinovic, Johannes-Matthias Löhr, Camilla Nøjgaard, Srdan Novovic, Johanna Laukkarinen, Mikael Parhiala, Lindkvist Björn, Anne Waage, Truls Hauge, Aldis Pukitis, Imanta Ozola-Zalite, Evangelos Kalaitzakis, Alexey Okhlobystin, Giederius Barauskas, Dahl Eva Efsen, Erling Tjora
Přispěvatelé: Tampere University, Department of Gastroenterology, Clinical Medicine
Rok vydání: 2022
Předmět:
Zdroj: Pancreatology
Scandinavian Baltic Pancreatic Clu 2022, ' Exocrine pancreas insufficiency in chronic pancreatitis-Risk factors and associations with complications. A multicentre study of 1869 patients ', Pancreatology, vol. 22, no. 3, pp. 374-380 . https://doi.org/10.1016/j.pan.2022.02.003
Erchinger, F, Engjom, T, Dimcevski, G, Drewes, A M, Olesen, S S, Vujasinovic, M, Löhr, J-M, Nøjgaard, C, Novovic, S, Laukkarinen, J, Parhiala, M, Lindkvist, B, Waage, A, Hauge, T, Pukitis, A, Ozola-Zalite, I, Kalaitzakis, E, Okhlobystin, A, Barauskas, G, Eva Efsen, D, Tjora, E & Scandinavian Baltic Pancreatic Club 2022, ' Exocrine pancreas insufficiency in chronic pancreatitis-Risk factors and associations with complications. A multicentre study of 1869 patients ', Pancreatology, vol. 22, no. 3, pp. 374-380 . https://doi.org/10.1016/j.pan.2022.02.003
ISSN: 1424-3903
DOI: 10.1016/j.pan.2022.02.003
Popis: Background/objectives: There is scarce information about risk factors for exocrine pancreas insufficiency (EPI) in chronic pancreatitis (CP), and how it associates with other complications. The aim of the present study was to examine risk factors for EPI and associations to procedures and other CP related complications in a large, Northern European cohort.Patients and methods: We retrieved cross-sectional data on demographics, status on EPI, aetiological risk factors for CP, CP related complications as well as surgical and endoscopic treatment from the Scandinavian Baltic Pancreatic Club Database. Associations were assessed by univariate and multivariate logistic regression analyses. Results are presented as odds ratios (OR) with 95% confidence intervals.Results: We included 1869 patients with probable or definitive CP in the study. Exocrine pancreas insufficiency was present in 849 (45.4%) of patients. In multivariate analyses, EPI associated with smoking aetiology (OR 1.47 (1.20-1.79), p < 0.001), and nutritional/metabolic aetiology (OR 0.52 (0.31-0.87), p = 0.01) to CP. Pancreatic or common bile duct stenting procedure and pancreatic resection were both associated with EPI (ORs 1.44 (1.15-1.80), p = 0.002 and 1.54 (1.02-2.33), p = 0.04, respectively). The presence of diabetes mellitus (OR 2.45 (1.92-3.15), p < 0.001), bile duct stenosis (OR 1.48 (1.09-2.00), p = 0.02) and underweight (2.05 (OR 1.40-3.02), p < 0.001) were all associated with presence of EPI.Conclusions: Smoking, bile duct stenosis, previous stenting and resection procedures are all associated with EPI in patients with CP. Presence of EPI were also associated with malnutrition and diabetes mellitus. Hence, intensive nutritional surveillance is needed in these patients. (C) 2022 The Authors. Published by Elsevier B.V. on behalf of IAP and EPC.
Databáze: OpenAIRE
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