Urinary bladder cancer test: a new urinary tumor marker in the follow-up of superficial bladder cancer

Autor: Chris M.G. Thomas, N.A. Mungan, Lambertus A. Kiemeney, J.A. Witjes, J.L.J. Vriesema
Rok vydání: 2000
Předmět:
Adult
Male
medicine.medical_specialty
Genetic epidemiology of transitional cell carcinoma of the urinary tract
(Patho)Physiological
endocrinological and methabolic aspects [Prevention of disorders in human reproduction]
Biopsy
Urology
Urinary system
Sensitivity and Specificity
Statistics
Nonparametric
Predictive Value of Tests
Development of assays for prognostic factors in oncological endocrinology
Biomarkers
Tumor
medicine
Carcinoma
Humans
De genetische epidemiologie van het urotheelcelcarcinoom
(Patho-)fysiologische
endocriene en metabole aspecten. [Preventie van stoornissen in de menselijke voortplanting]
Aged
Neoplasm Staging
Tumor marker
Aged
80 and over
Urinary bladder
medicine.diagnostic_test
business.industry
Carcinoma in situ
fungi
Cystoscopy
Middle Aged
medicine.disease
Surgery
medicine.anatomical_structure
ROC Curve
Urinary Bladder Neoplasms
Creatinine
Predictive value of tests
Ontwikkeling van meetmethodes voor prognostische factoren in de oncologische endocrinologie
Keratins
Regression Analysis
Female
Neoplasm Recurrence
Local
Superficial Bladder Carcinoma
business
Carcinoma in Situ
Follow-Up Studies
Zdroj: Urology, 56, 5, pp. 787-791
Urology, 56, 787-791
ISSN: 0090-4295
DOI: 10.1016/S0090-4295(00)00798-6
Popis: Objectives. To study the diagnostic performance of the Urinary Bladder Cancer (UBC) test in patients with superficial bladder carcinoma. Methods. One hundred one patients in follow-up for superficial bladder cancer (pTa, pT1, carcinoma in situ) were recruited for this study. Each patient underwent cystoscopy and transurethral resection or biopsy, with subsequent histologic confirmation in the case of abnormalities. In addition, specimens were assessed with an immunoenzymometric assay for cytokeratin expression (the UBC test), and the urinary creatinine concentration was determined to correct for different degrees of urinary dilution. Different methods were applied to calculate the diagnostic value of the UBC test. Results. Both noncorrected and corrected median values of the UBC test were comparable between patients with and without a recurrent bladder tumor. The overall sensitivity, specificity, and positive and negative predictive values of the noncorrected UBC test was 20.7%, 84.7%, 35.3%, and 72.6%, respectively. For the corrected UBC test, the corresponding values were 20.7%, 79.2%, 28.6%, and 71.3%. The area under the receiver operating characteristic curve was not significantly different from 0.50, indicating no diagnostic value of the UBC test in this study. Conclusions. The diagnostic value of this new urinary marker appears insufficient for the follow-up of patients with superficial bladder cancer.
Databáze: OpenAIRE
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