Citric acid coated magnetite nanoparticles to overcome intrinsic rifampicin resistance in Mycobacterium smegmatis
| Autor: | Sarika Mehra, Priyanka Padwal, Rajdip Bandyopadhyaya |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Pathology
medicine.medical_specialty biology Mycobacterium smegmatis Nanoparticle Drug resistance ePoster presentation biology.organism_classification chemistry.chemical_compound Infectious Diseases chemistry Permeability (electromagnetism) Transmission electron microscopy medicine Biophysics Efflux Ethidium bromide Citric acid |
| Zdroj: | BMC Infectious Diseases |
| ISSN: | 1471-2334 |
| Popis: | Methods We have studied the effect of rifampicin on growth of cells, with and without the nanoparticles. Further, cellular uptake of nanoparticles was studied by transmission electron microscopy. Since, permeability barrier and drug efflux are responsible for intrinsic drug resistance, we have performed accumulation and efflux studies on common efflux pump substrate ethidium bromide (EtBr) by semi automated fluorometric method in the presence and absence of nanoparticles. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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