Effect of Angiotensin II Receptor Blockade on Fibrinolysis During Acute Hyperinsulinemia in Patients With Essential Hypertension
| Autor: | Endre Sandvik, Ingebjørg Seljeflot, Sverre E. Kjeldsen, Harald Arnesen, Andreas Moan |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Angiotensin receptor medicine.medical_treatment Tetrazoles Essential hypertension Losartan Angiotensin Receptor Antagonists Catecholamines Double-Blind Method Hyperinsulinism Internal medicine Fibrinolysis Internal Medicine medicine Hyperinsulinemia Humans Antihypertensive Agents Aged Glucose tolerance test Cross-Over Studies medicine.diagnostic_test business.industry Biphenyl Compounds Imidazoles Glucose Tolerance Test Middle Aged medicine.disease Angiotensin II Endocrinology Tissue Plasminogen Activator Hypertension Female business Plasminogen activator medicine.drug |
| Zdroj: | Hypertension. 27:1299-1304 |
| ISSN: | 1524-4563 0194-911X |
| Popis: | Abstract We performed the present study to investigate indirectly the in vivo effects of angiotensin II on fibrinolysis and catecholamines by treatment with losartan, a selective angiotensin II type 1 receptor antagonist. The effects were evaluated in basal conditions as well as in two different models of acute hyperinsulinemia physiologically induced by oral glucose ingestion and by a euglycemic glucose clamp technique. Twenty subjects with moderate hypertension were included in a randomized, double-blind, placebo-controlled crossover study of 4-week treatment periods. Plasma levels of catecholamines, tissue plasminogen activator activity and antigen, and plasminogen activator inhibitor type 1 activity and antigen were unchanged in the basal state after 4 weeks of treatment. During both models of hyperinsulinemia, plasminogen activator inhibitor activity and antigen decreased significantly (both P P |
| Databáze: | OpenAIRE |
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