Small DNA circles as probes of DNA topology

Autor:	Anthony Maxwell, Sarah A. Harris, Agnes Noy, Andrew D. Bates, Michael M. Piperakis
Rok vydání:	2013
Předmět:	Proteins Molecular models of DNA Nanotechnology Computational biology Molecular Dynamics Simulation Biology Biochemistry chemistry.chemical_compound Molecular dynamics chemistry Molecular Probes Animals Humans DNA Circular Topology (chemistry) DNA Protein Binding
Zdroj:	Biochemical Society Transactions. 41:565-570
ISSN:	1470-8752 0300-5127
Popis:	Small DNA circles can occur in Nature, for example as protein-constrained loops, and can be synthesized by a number of methods. Such small circles provide tractable systems for the study of the structure, thermodynamics and molecular dynamics of closed-circular DNA. In the present article, we review the occurrence and synthesis of small DNA circles, and examine their utility in studying the properties of DNA and DNA–protein interactions. In particular, we highlight the analysis of small circles using atomistic simulations.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18bbcf6e61c5341409814968e9a0bde8 https://doi.org/10.1042/bst20120320 Zobrazit plný text záznamu